SARS-CoV-2 Infektionsimmunologie

Wir arbeiten an verschiedenen Aspekten zur SARS-CoV-2 Pandemie: Suche nach neuen antiviralen Substanzen, Charakterisierung der Infektiosität, Entwicklung von Antikörpertests, Untersuchungen zur Dauer der Immunität, Neutralisierung von Virusvarianten und Immun-Escape.

Publikationen:

  • Wiest C, Philipp A, Lunz D, Steinmann JF, Eissnert C, Kees M, Kieninger M, Dienemann T, Ritzka M, Schweiger S, Pross A, Fisser C, Malfertheiner M, Schneckenpointner R, Lange TJ, Schulz C, Geismann F, Foltan M, Schettler F, Salzberger B, Hitzenbichler F, Hanses F, Schmidt B, Arzt M, Sinner B, Graf B, Maier LS, Müller T, Lubnow M. Langzeitunterstützung mit veno-venöser extrakorporaler Membranoxygenierung bei Patienten mit COVID-19 – eine retrospektive Analyse des ECMO-Zentrums Regensburg. Dtsch Arztebl 2022; 28. Oktober 2022; DOI: 10.3238/arztebl.m2022.0354.
  • Magnus CL, Schmidt B. SARS-CoV-2 Vaccine Against Virus: Mission Accomplished!? In: S. Adibi et al. (eds.), Frontiers of COVID-19: Scientific and Clinical Aspects of the Novel Coronavirus 2019. Springer Nature 2022. https://doi.org/10.1007/978-3-031-08045-6_27.
  • Heinl ES, Lorenz S, Schmidt B, Nasser M Laqtom N, Mazzulli JR, Francelle L, Yu TW, Greenberg B, Storch S, Tegtmeier I, Othmen H, Maurer K, Steinfurth M, Witzgall R, Milenkovic V, Wetzel CH, Reichold M. CLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry. iScience. 2022 Oct 21;25(10):105082. doi: 10.1016/j.isci.2022.105082.
  • Magnus CL, Hiergeist A, Schuster P, Rohrhofer A, Medenbach J, Gessner A, Peterhoff D, Schmidt B. Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab. Front Immunol. 2022 Aug 24;13:966236. doi: 10.3389/fimmu.2022.966236.
  • Bauernfeind S, Schmidt B. Stellenwert der COVID-19-Impfung im Kontext von Long-COVID [The value of COVID-19 vaccination in the context of Long-COVID]. Inn Med (Heidelb). 2022 Aug;63(8):840-850. German. doi: 10.1007/s00108-022-01368-y. Epub 2022 Jul 7.
  • Meister TL, Gottsauner JM, Schmidt B, Heinen N, Todt D, Audebert F, Buder F, Lang H, Gessner A, Steinmann E, Vielsmeier V, Pfaender S, Cieplik F. Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial. Virus Res. 2022 Jul 15;316:198791. doi: 10.1016/j.virusres.2022.198791.
  • Glück V, Tydykov L, Mader AL, Warda AS, Bertok M, Weidlich T, Gottwald C, Köstler J, Salzberger B, Wagner R, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D. Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19-convalescent subjects. Infection. 2022 Apr 11:1–7. doi: 10.1007/s15010-022-01817-8.
  • Mader AL, Tydykov L, Glück V, Bertok M, Weidlich T, Gottwald C, Stefl A, Vogel M, Plentz A, Köstler J, Salzberger B, Wenzel JJ, Niller HH, Jantsch J, Wagner R, Schmidt B, Glück T, Gessner A, Peterhoff D. Omicron’s binding to sotrovimab, casirivimab, imdevimab, CR3022, and sera from previously infected or vaccinated individuals. iScience. 2022 Apr 15;25(4):104076. doi: 10.1016/j.isci.2022.104076.
  • Bauswein M, Peterhoff D, Plentz A, Hiergeist A, Wagner R, Gessner A, Salzberger B, Schmidt B, Bauernfeind S. Increased neutralization of SARS-CoV-2 Delta variant after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination. iScience. 2022 Feb 18;25(2):103694. doi: 10.1016/j.isci.2021.103694.
  • Buder F, Bauswein M, Magnus CL, Audebert F, Lang H, Kundel C, Distler K, Reuschel E, Lubnow M, Müller T, Lunz D, Graf B, Schmid S, Müller M, Poeck H, Hanses F, Salzberger B, Peterhoff D, Wenzel JJ, Schmidt B, Lampl BMJ. Contribution of High Viral Loads, Detection of Viral Antigen and Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 Infectivity. J Infect Dis. 2022 Jan 18;225(2):190-198. doi: 10.1093/infdis/jiab415. Erratum in: J Infect Dis. 2022 Jul 23.
  • Glück V, Grobecker S, Köstler J, Tydykov L, Bertok M, Weidlich T, Gottwald C, Salzberger B, Wagner R, Zeman F, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D. Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel. Infection. 2021 Sep 25:1-8.
  • Evert K, Dienemann T, Brochhausen C, Lunz D, Lubnow M, Ritzka M, Keil F, Trummer M, Scheiter A, Salzberger B, Reischl U, Boor P, Gessner A, Jantsch J, Calvisi DF, Evert M, Schmidt B, Simon M. Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation. Virchows Arch. 2021 Jul;479(1):97-108.
  • Bauernfeind S, Hitzenbichler F, Huppertz G, Zeman F, Koller M, Schmidt B, Plentz A, Bauswein M, Mohr A, Salzberger B. Brief report: attitudes towards Covid-19 vaccination among hospital employees in a tertiary care university hospital in Germany in December 2020. Infection. 2021 May 20:1–5.
  • Dugas M, Grote-Westrick T, Merle U, Fontenay M, Kremer AE, Hanses F, Vollenberg R, Lorentzen E, Tiwari-Heckler S, Duchemin J, Ellouze S, Vetter M, Fürst J, Schuster P, Brix T, Denkinger CM, Müller-Tidow C, Schmidt H, Tepasse PR, Kühn J. Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19. J Clin Virol 2021 Apr 24, 104847 (in press).
  • Werner M, Pervan P, Glück V, Zeman F, Koller M, Burkhardt R, Glück T, Wenzel JJ, Schmidt B, Gessner A, Peterhoff D. Evaluation of a Broad Panel of SARS-CoV-2 Serological Tests for Diagnostic Use.  J Clin Med. 2021 Apr 8;10(8):1580.
  • Salzberger B, Buder F, Lampl B, Ehrenstein B, Hitzenbichler F, Holzmann T, Schmidt B, Hanses F. Epidemiology of SARS-CoV-2. Infection. 2021 Apr;49(2):233-239.
  • Hitzenbichler F, Bauernfeind S, Salzberger B, Schmidt B, Wenzel JJ. Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2. Viruses. 2021 Apr 10;13(4):653.
  • Glück V, Grobecker S, Tydykov L, Salzberger B, Glück T, Weidlich T, Bertok M, Gottwald C, Wenzel JJ, Gessner A, Schmidt B, Peterhoff D. SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19. Infection. 2021 Mar 10:1-8.
  • Dreier E, Malfertheiner MV, Dienemann T, Fisser C, Foltan M, Geismann F, Graf B, Lunz D, Maier LS, Müller T, Offner R, Peterhoff D, Philipp A, Salzberger B, Schmidt B, Sinner B, Lubnow M. ECMO in COVID-19-prolonged therapy needed? A retrospective analysis of outcome and prognostic factors. Perfusion. 2021 Feb 20:267659121995997.
  • De Pellegrin ML, Rohrhofer A, Schuster P, Schmidt B, Peterburs P, Gessner A. The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study. Clinical Phytoscience. 2021 Mar 7: 29.
  • Peterhoff D, Glück V, Vogel M, Schuster P, Schütz A, Neubert P, Albert V, Frisch S, Kiessling M, Pervan P, Werner M, Ritter N, Babl L, Deichner M, Hanses F, Lubnow M, Müller T, Lunz D, Hitzenbichler F, Audebert F, Hähnel V, Offner R, Müller M, Schmid S, Burkhardt R, Glück T, Koller M, Niller HH, Graf B, Salzberger B, Wenzel JJ, Jantsch J, Gessner A, Schmidt B, Wagner R. A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization. Infection. 2021 Feb;49(1):75-82.
  • Lubnow M, Schmidt B, Fleck M, Salzberger B, Müller T, Peschel G, Schneckenpointner R, Lange T, Hitzenbichler F, Kieninger M, Lunz D, Graf B, Brochhausen C, Weber F, Lüke F, Peterhoff D, Schuster P, Hiergeist A, Offner R, Hehr U, Wallner S, Hanses F, Schmid S, Weigand K, Geismann F, Poeck H, Pukrop T, Evert M, Gessner A, Burkhardt R, Herr W, Maier LS, Heudobler D. Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson’s disease: Balancing immunosuppression. Int J Infect Dis. 2021 Feb;103:624-627.
  • Hähnel V, Peterhoff D, Bäuerlein V, Brosig AM, Pamler I, Johnson C, Bica A, Totir M, Ossner T, Stemmer B, Toelge M, Schütz A, Niller HH, Schmidt B, Wagner R, Gessner A, Burkhard R, Offner R. Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality. PLoS One. 2020 Dec 22;15(12):e0243967.
  • Gottsauner MJ, Michaelides I, Schmidt B, Scholz KJ, Buchalla W, Widbiller M, Hitzenbichler F, Ettl T, Reichert TE, Bohr C, Vielsmeier V, Cieplik F. A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2. Clin Oral Investig. 2020 Oct;24(10):3707-3713.
  • Kabesch M, Roth S, Brandstetter S, Häusler S, Juraschko E, Weigl M, Wellmann S, Lang T, Schmidt B, Salzberger B, Ambrosch A. Successful containment of Covid-19 outbreak in a large maternity and perinatal center while continuing clinical service. Pediatr Allergy Immunol. 2020 Jul;31(5):560-564.
  • Lüke F, Orsó E, Kirsten J, Poeck H, Grube M, Wolff D, Burkhardt R, Lunz D, Lubnow M, Schmidt B, Hitzenbichler F, Hanses F, Salzberger B, Evert M, Herr W, Brochhausen C, Pukrop T, Reichle A, Heudobler D. Coronavirus disease 2019 induces multi-lineage, morphologic changes in peripheral blood cells. EJHaem. 2020 Jun 29:10.1002/jha2.44.
  • Eis-Hübinger AM, Hönemann M, Wenzel JJ, Berger A, Widera M, Schmidt B, Aldabbagh S, Marx B, Streeck H, Ciesek S, Liebert UG, Huzly D, Hengel H, Panning M. Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples. J Clin Virol. 2020 Jun;127:104381.