Dr. Andreas Hiergeist
Leiter der Core Facility
Telefon +49 (0) 941 - 944-16465
Telefax +49 (0) 941 - 944 6402
 E-Mail  andreas.hiergeist@ukr.de
Prof. Dr. Dr. André Gessner
Telefon +49 (0) 941 - 944-6400
Telefax +49 (0) 941 - 944 6407
E-Mail andre.gessner@ukr.de


Peuker, K., Strigli, A., Tauriello, D. V. F., Hendricks, A., von Schönfels, W., Burmeister, G., Brosch, M., Herrmann, A., Krüger, S., Nitsche, J., Južnić, L., Geissler, M. M., Hiergeist, A., Gessner, A., Wirbel, J., Ponnudurai, R. P., Tunger, A., Wehner, R., Stange, D. E., Weitz, J., Aust, D. E., Baretton, G. B., Schmitz, M., Röcken, C., Hampe, J., Hinz, S., Zeller, G., Chavakis, T., Schafmayer, C., Batlle, E. and Zeissig, S. (2022), 'Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.', Immunity.

Meedt, E., Hiergeist, A., Gessner, A., Dettmer, K., Liebisch, G., Ghimire, S., Poeck, H., Edinger, M., Wolff, D., Herr, W., Holler, E. and Weber, D. (2022), 'Prolonged Suppression of Butyrate-Producing Bacteria Is Associated With Acute Gastrointestinal Graft-vs-Host Disease and Transplantation-Related Mortality After Allogeneic Stem Cell Transplantation.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 74, 614--621.

Ghazavi, F., Huysentruyt, J., De Coninck, J., Kourula, S., Martens, S., Hassannia, B., Wartewig, T., Divert, T., Roelandt, R., Popper, B., Hiergeist, A., Tougaard, P., Vanden Berghe, T., Joossens, M., Berx, G., Takahashi, N., Wahida, A. and Vandenabeele, P. (2022), 'Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.', Proceedings of the National Academy of Sciences of the United States of America 119.

Wahida, A., Müller, M., Hiergeist, A., Popper, B., Steiger, K., Branca, C., Tschurtschenthaler, M., Engleitner, T., Donakonda, S., De Coninck, J., Öllinger, R., Pfautsch, M. K., Müller, N., Silva, M., Usluer, S., Thiele Orberg, E., Böttcher, J. P., Pfarr, N., Anton, M., Slotta-Huspenina, J. B., Nerlich, A. G., Madl, T., Basic, M., Bleich, A., Berx, G., Ruland, J., Knolle, P. A., Rad, R., Adolph, T. E., Vandenabeele, P., Kanegane, H., Gessner, A., Jost, P. J. and Yabal, M. (2021), 'XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.', Science immunology 6, eabf7235.

Basic, M., Bolsega, S., Smoczek, A., Gläsner, J., Hiergeist, A., Eberl, C., Stecher, B., Gessner, A. and Bleich, A. (2021), 'Monitoring and contamination incidence of gnotobiotic experiments performed in microisolator cages.', International journal of medical microbiology : IJMM 311, 151482.

Ghimire, S., Weber, D., Hippe, K., Meedt, E., Hoepting, M., Kattner, A.-S., Hiergeist, A., Gessner, A., Matos, C., Ghimire, S., Wolff, D., Edinger, M., Hoffmann, P., Poeck, H., Herr, W. and Holler, E. (2021), 'GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics.', Frontiers in immunology 12, 753287.

de Castilhos, J., Zamir, E., Hippchen, T., Rohrbach, R., Schmidt, S., Hengler, S., Schumacher, H., Neubauer, M., Kunz, S., Müller-Esch, T., Hiergeist, A., Gessner, A., Khalid, D., Gaiser, R., Cullin, N., Papagiannarou, S. M., Beuthien-Baumann, B., Krämer, A., Bartenschlager, R., Jäger, D., Müller, M., Herth, F., Duerschmied, D., Schneider, J., Schmid, R. M., Eberhardt, J. F., Khodamoradi, Y., Vehreschild, M. J. G. T., Teufel, A., Ebert, M. P., Hau, P., Salzberger, B., Schnitzler, P., Poeck, H., Elinav, E., Merle, U. and Stein-Thoeringer, C. K. (2021), 'Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Schwarz, S. R., Hirsch, S., Hiergeist, A., Kirschneck, C., Muehler, D., Hiller, K.-A., Maisch, T., Al-Ahmad, A., Gessner, A., Buchalla, W. and Cieplik, F. (2021), 'Limited antimicrobial efficacy of oral care antiseptics in microcosm biofilms and phenotypic adaptation of bacteria upon repeated exposure.', Clinical oral investigations 25, 2939--2950.

Lubnow, M., Schmidt, B., Fleck, M., Salzberger, B., Müller, T., Peschel, G., Schneckenpointner, R., Lange, T., Hitzenbichler, F., Kieninger, M., Lunz, D., Graf, B., Brochhausen, C., Weber, F., Lüke, Cieplik, F., Wiedenhofer, A. M., Pietsch, V., Hiller, K.-A., Hiergeist, A., Wagner, A., Baldaranov, D., Linker, R. A., Jantsch, J., Buchalla, W., Schlachetzki, F. and Gessner, A. (2020), 'Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia-A Prospective Observational Study.', Frontiers in neurology 11, 528056.

Hiergeist, A., Gessner, J. and Gessner, A. (2020), 'Current Limitations for the Assessment of the Role of the Gut Microbiome for Attention Deficit Hyperactivity Disorder (ADHD).', Frontiers in psychiatry 11, 623.

Bülow, S., Heyd, R., Toelge, M., Ederer, K. U., Schweda, A., Blaas, S. H., Hamer, O. W., Hiergeist, A., Wenzel, J. J. and Gessner, A. (2020), 'Lipopolysaccharide Binding Protein and Bactericidal/Permeability-Increasing Protein as Biomarkers for Invasive Pulmonary Aspergillosis.', Journal of fungi (Basel, Switzerland) 6.

Berger, F. K., Mellmann, A., von Müller, L., Bischoff, M., Gärtner, B. C. and speaking C. difficile laboratory study group, G. (2020), 'Quality assurance for genotyping and resistance testing of Clostridium (Clostridioides) difficile isolates - Experiences from the first inter-laboratory ring trial in four German speaking countries.', Anaerobe 61, 102093.

Schmidtner, A. K., Slattery, D. A., Gläsner, J., Hiergeist, A., Gryksa, K., Malik, V. A., Hellmann-Regen, J., Heuser, I., Baghai, T. C., Gessner, A., Rupprecht, R., Di Benedetto, B. and Neumann, I. D. (2019), 'Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner.', Translational psychiatry 9, 223.

Weber, D., Hiergeist, A., Weber, M., Dettmer, K., Wolff, D., Hahn, J., Herr, W., Gessner, A. and Holler, E. (2019), 'Detrimental Effect of Broad-spectrum Antibiotics on Intestinal Microbiome Diversity in Patients After Allogeneic Stem Cell Transplantation: Lack of Commensal Sparing Antibiotics.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 68, 1303--1310.

Hiergeist, A. and Gessner, A. (2018), '[The human intestinal microbiome and why you have to think twice before prescribing antibiotics!]', MMW Fortschritte der Medizin 160, 58--62.

Brenner, D., Hiergeist, A., Adis, C., Mayer, B., Gessner, A., Ludolph, A. C. and Weishaupt, J. H. (2018), 'The fecal microbiome of ALS patients.', Neurobiology of aging 61, 132--137.

Hiergeist, A. and Gessner, A. (2017), 'Clinical implications of the microbiome in urinary tract diseases.', Current opinion in urology 27, 93--98.

Weber, D., Frauenschläger, K., Ghimire, S., Peter, K., Panzer, I., Hiergeist, A., Weber, M., Kutny, D., Wolff, D., Grube, M., Huber, E., Oefner, P., Gessner, A., Hehlgans, T., Herr, W. and Holler, E. (2017), 'The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation.', PloS one 12, e0185265.

Simon, M., Melzl, H., Hiergeist, A., Richert, K., Falgenhauer, L., Pfeifer, Y., Gerlach, R. G., Fuchs, K., Reischl, U., Gessner, A. and Jantsch, J. (2017), 'Colistin- and carbapenem-resistant Klebsiella oxytoca harboringblaVIM-2 and an insertion in the mgrB gene isolated from blood culture', International journal of medical microbiology : IJMM 307, 113--115.

Weber, D., Jenq, R. R., Peled, J. U., Taur, Y., Hiergeist, A., Koestler, J., Dettmer, K., Weber, M., Wolff, D., Hahn, J., Pamer, E. G., Herr, W., Gessner, A., Oefner, P. J., van den Brink, M. R. M. and Holler, E. (2017), 'Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.', Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, 845--852.

Bouazzaoui, A., Huber, E., Dan, A., Al-Allaf, F. A., Pfirstinger, J., Sprotte, G., Köstler, J., Hiergeist, A., Gessner, A., Herr, W. and Holler, E. (2017), 'Reduction of aGVHD using chicken antibodies directed against intestinal pathogens in a murine model.', Blood 129, 1052--1055.

Eigner, U., Hiergeist, A., Veldenzer, A., Rohlfs, M., Schwarz, R. and Holfelder, M. (2017), 'Evaluation of a new real-time PCR assay for the direct detection of diarrheagenic Escherichia coli in stool specimens.', Diagnostic microbiology and infectious disease 88, 12--16.

Kikhney, J., von Schöning, D., Steding, I., Schulze, J., Petrich, A., Hiergeist, A., Reischl, U., Moter, A. and Thomas, A. (2017), 'Is Ureaplasma spp. the leading causative agent of acute chorioamnionitis in women with preterm birth?', Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 23, 119.e1--119.e7.

Altenbuchinger, M., Rehberg, T., Zacharias, H. U., Stämmler, F., Dettmer, K., Weber, D., Hiergeist, A., Gessner, A., Holler, E., Oefner, P. J. and Spang, R. (2017), 'Reference point insensitive molecular data analysis.', Bioinformatics (Oxford, England) 33, 219--226.

Hiergeist, A., Reischl, U., quality assessment participants , P. P. 1656. I. M. C. and Gessner, A. (2016), 'Multicenter quality assessment of 16S ribosomal DNA-sequencing for microbiome analyses reveals high inter-center variability.', International journal of medical microbiology : IJMM 306, 334--342.

Clavel, T., Lagkouvardos, I. and Hiergeist, A. (2016), 'Microbiome sequencing: challenges and opportunities for molecular medicine.', Expert review of molecular diagnostics 16, 795--805.

Stämmler, F., Gläsner, J., Hiergeist, A., Holler, E., Weber, D., Oefner, P. J., Gessner, A. and Spang, R. (2016), 'Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.', Microbiome 4, 28.

Kesselring, R., Glaesner, J., Hiergeist, A., Naschberger, E., Neumann, H., Brunner, S. M., Wege, A. K., Seebauer, C., Köhl, G., Merkl, S., Croner, R. S., Hackl, C., Stürzl, M., Neurath, M. F., Gessner, A., Schlitt, H.-J., Geissler, E. K. and Fichtner-Feigl, S. (2016), 'IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3.', Cancer cell 29, 684--696.

Krzyzak, L., Seitz, C., Urbat, A., Hutzler, S., Ostalecki, C., Gläsner, J., Hiergeist, A., Gessner, A., Winkler, T. H., Steinkasserer, A. and Nitschke, L. (2016), 'CD83 Modulates B Cell Activation and Germinal Center Responses.', Journal of immunology (Baltimore, Md. : 1950) 196, 3581--3594.

Weber, D., Oefner, P. J., Dettmer, K., Hiergeist, A., Koestler, J., Gessner, A., Weber, M., Stämmler, F., Hahn, J., Wolff, D., Herr, W. and Holler, E. (2016), 'Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation.', Bone marrow transplantation 51, 1087--1092.

Manook, A., Hiergeist, A., Rupprecht, R. and Baghai, T. C. (2016), '[Gut microbiome and major depressive disorder : The other side of ourselves].', Der Nervenarzt 87, 1227--1240.

Weber, D., Oefner, P. J., Hiergeist, A., Koestler, J., Gessner, A., Weber, M., Hahn, J., Wolff, D., Stämmler, F., Spang, R., Herr, W., Dettmer, K. and Holler, E. (2015), 'Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome.', Blood 126, 1723--1728.

Hiergeist, A., Gläsner, J., Reischl, U. and Gessner, A. (2015), 'Analyses of Intestinal Microbiota: Culture versus Sequencing.', ILAR journal 56, 228--240.