Interactions between AB and AC

Drug-drug interactions account for 4% of death of cancer patients. Antibiotics (AB) and antineoplastic agents (AC) are characterized by their narrow therapeutic index and high inter-individual variability.

Project: Explore potential interactions between AB and AC through:

a) evaluation of potential displacement of AB from plasma proteins by AC drugs and its implications in the assessment of AB-AC interactions (ex vivo), and

b) investigation of potential effect of combination therapy between AC drugs and AB on the inhibitory effects of antineoplastic activity of AC drugs (in vitro).

drug drug