Aktueller Stand 13.01.22: 40 Publikationen zur Coronavirus-Forschung wurden unter Beteiligung des Instituts für Mikrobiologie und Hygiene bislang veröffentlicht:
Niedrige Inzidenz von SARS-CoV-2-Infektionen bei Krankenhausmitarbeitern eines Maximalversorgers
Ergebnisse einer prospektiven serologischen Kohortenstudie der ersten und zweiten COVID-19-Welle
Hupf J., Burkhardt R., ·Gessner A., Maier-Stocker, C., Zimmermann M., Hanses F., ·Peterhoff D.
Med Klin Intensivmed Notfmed https://doi.org/10.1007/s00063-021-00890-51
Neutralization of SARS-CoV-2 Delta variant is increased after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination.
Bauswein M, Peterhoff D, Plentz A, Hiergeist A, Wagner R, Gessner A, Salzberger B, Schmidt B, Bauernfeind S.
iScience. 2022 Jan 5:103694. doi: 10.1016/j.isci.2021.103694. Online ahead of print.PMID: 35013723 Free PMC article.
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Valero J, Civit L, Dupont DM, Selnihhin D, Reinert LS, Idorn M, Israels BA, Bednarz AM, Bus C, Asbach B, Peterhoff D, Pedersen FS, Birkedal V, Wagner R, Paludan SR, Kjems J.
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2112942118. doi: 10.1073/pnas.2112942118.PMID: 34876524
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases.
Castillo-Olivares J, Wells DA, Ferrari M, Chan ACY, Smith P, Nadesalingam A, Paloniemi M, Carnell GW, Ohlendorf L, Cantoni D, Mayora-Neto M, Palmer P, Tonks P, Temperton NJ, Peterhoff D, Neckermann P, Wagner R, Doffinger R, Kempster S, Otter AD, Semper A, Brooks T, Albecka A, James LC, Page M, Schwaeble W, Baxendale H, Heeney JL.
Front Immunol. 2021 Nov 19;12:748291. doi: 10.3389/fimmu.2021.748291. eCollection 2021.PMID: 34867975 Free PMC article.
Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone.
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K.
J Clin Invest. 2021 Nov 15;131(22):e148225. doi: 10.1172/JCI148225.PMID: 34779418
Symptoms, SARS-CoV-2 Antibodies, and Neutralization Capacity in a Cross Sectional-Population of German Children.
Laub O, Leipold G, Toncheva AA, Peterhoff D, Einhauser S, Neckermann P, Borchers N, Santos-Valente E, Kheiroddin P, Buntrock-Döpke H, Laub S, Schöberl P, Schweiger-Kabesch A, Ewald D, Horn M, Niggel J, Ambrosch A, Überla K, Gerling S, Brandstetter S, Wagner R, Kabesch M; Corona Virus Antibodies in Children from Bavaria (CoKiBa) Study Group.
Front Pediatr. 2021 Oct 4;9:678937. doi: 10.3389/fped.2021.678937. eCollection 2021.PMID: 34671582
SARS-CoV-2 transmission during an indoor professional sporting event.
Pauser J, Schwarz C, Morgan J, Jantsch J, Brem M.
Sci Rep. 2021 Oct 20;11(1):20723. doi: 10.1038/s41598-021-99997-0.PMID: 34671096
Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2.
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D.
Vaccines (Basel). 2021 Sep 27;9(10):1089. doi: 10.3390/vaccines9101089.PMID: 34696197
Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients.
de Castilhos J, Zamir E, Hippchen T, Rohrbach R, Schmidt S, Hengler S, Schumacher H, Neubauer M, Kunz S, Müller-Esch T, Hiergeist A, Gessner A, Khalid D, Gaiser R, Cullin N, Papagiannarou SM, Beuthien-Baumann B, Krämer A, Bartenschlager R, Jäger D, Müller M, Herth F, Duerschmied D, Schneider J, Schmid RM, Eberhardt JF, Khodamoradi Y, Vehreschild MJGT, Teufel A, Ebert MP, Hau P, Salzberger B, Schnitzler P, Poeck H, Elinav E, Merle U, Stein-Thoeringer CK.
Clin Infect Dis. 2021 Oct 25:ciab902. doi: 10.1093/cid/ciab902. Online ahead of print.PMID: 34694375
Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests-A Population-Based Evaluation.
Einhauser S, Peterhoff D, Niller HH, Beileke S, Günther F, Steininger P, Burkhardt R, Heid IM, Pfahlberg AB, Überla K, Gefeller O, Wagner R.
Diagnostics (Basel). 2021 Oct 6;11(10):1843. doi: 10.3390/diagnostics11101843.PMID: 34679541 Free PMC article.
Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.
Glück V, Grobecker S, Köstler J, Tydykov L, Bertok M, Weidlich T, Gottwald C, Salzberger B, Wagner R, Zeman F, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D.
Infection. 2021 Sep 25. doi: 10.1007/s15010-021-01703-9. Online ahead of print.PMID: 34562263
Association between reactogenicity and immunogenicity after vaccination with BNT162b2
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D.
Vaccines, received 4 August 21, accepted for publication
Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses.
Sampson AT, Heeney J, Cantoni D, Ferrari M, Sans MS, George C, Di Genova C, Mayora Neto M, Einhauser S, Asbach B, Wagner R, Baxendale H, Temperton N, Carnell G.
Viruses. 2021 Aug 10;13(8):1579. doi: 10.3390/v13081579.PMID: 34452443
SARS-CoV-2 infectivity correlates with high viral loads and detection of viral antigen and is terminated by seroconversion.
Buder F, Bauswein M, Magnus CL, Audebert F, Lang H, Kundel C, Distler K, Reuschel E, Lubnow M, Müller T, Lunz D, Graf B, Schmid S, Müller M, Poeck H, Hanses F, Salzberger B, Peterhoff D, Wenzel J.J., Schmidt B, Lampl BMJ. J Infect Dis. 2021 Aug 24:jiab415. doi: 10.1093/infdis/jiab415. Online ahead of print.
Paucity and discordance of neutralising antibody responses to SARS-CoV-2 VOCs in vaccinated immunodeficient patients and health-care workers in the UK.
Nadesalingam A, Cantoni D, Wells DA, Aguinam ET, Ferrari M, Smith P, Chan A, Carnell G, Ohlendorf L, Einhauser S, George C, Wagner R, Temperton N, Castillo-Olivares J, Baxendale H, Heeney JL; HICC consortium. Lancet Microbe. 2021 Jun 28. doi: 10.1016/S2666-5247(21)00157-9. Online ahead of print.PMID: 34223399 Free PMC article.
Brief report: attitudes towards Covid-19 vaccination among hospital employees in a tertiary care university hospital in Germany in December 2020.
Bauernfeind S, Hitzenbichler F, Huppertz G, Zeman F, Koller M, Schmidt B, Plentz A, Bauswein M, Mohr A, Salzberger B. Infection. 2021 May 20:1–5.
Estimates and determinants of SARS-CoV-2 seroprevalence and infection fatality ratio using latent class analysis: the population-based Tirschenreuth study in the hardest-hit German county in spring 2020
Wagner R., Peterhoff D., Beileke S., Guenther D., Berr M., Einhauser S., Schuetz A., Niller H.H., Steininger P., Knoell A., Tenbusch M., Maier C., Korn K., Stark K., Gessner A., Burkhardt R., Kabesch M., Schedl H., Küchenhoff H., Pfahlberg A., Heid I., Gefeller O., Überla K.; MDPI Viruses, 2021 doi:10.1101/2021.03.29.21254343
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Renner K, Schwittay T, Chaabane S, Gottschling J, Müller C, Tiefenböck C, Salewski JN, Winter F, Buchtler S, Balam S, Malfertheiner MV, Lubnow M, Lunz D, Graf B, Hitzenbichler F, Hanses F, Poeck H, Kreutz M, Orsó E, Burkhardt R, Niedermair T, Brochhausen C, Gessner A, Salzberger B, Mack M. Nat Commun. 2021 May 21;12(1):3006. doi: 10.1038/s41467-021-23334-2.
Pooling for SARS-CoV-2-testing: comparison of three commercially available RT-qPCR kits in an experimental approach
Cibali E, Wenzel JJ, Gruber R, Ambrosch A; Chem Lab Med 2021, 59(6):e243-e245.
Psychophysical tests reveal impaired olfaction but preserved gustation in COVID-19 patients
Hintschich CA, Wenzel JJ, Hummel T, Hankir MK, Kühnel T, Vielsmeier V, Bohr C. Int Forum Allergy Rhinol 2020, 10(9):1105-1107.
SARS-CoV-2 spike protein stabilized in the closed state induces potent neutralizing responses.
Carnell GW, Ciazynska KA, Wells DA, Xiong X, Aguinam ET, McLaughlin SH, Mallery D, Ebrahimi S, Ceron-Gutierrez L, Asbach B, Einhauser S, Wagner R, James LC, Doffinger R, Heeney JL, Briggs JAG. J Virol. 2021 May 7:JVI.00203-21. doi: 10.1128/JVI.00203-21. Online ahead of print.PMID: 33963055
Serum neurofilament light chain (sNfL) values in a large cross‑sectional population of children with asymptomatic to moderate COVID‑19
Geis T.,·Brandstetter S., Toncheva A.A., Laub O., Leipold G., ·Wagner R., Kabesch M., Kasser S., Kuhle J., Wellmann S.,· CoKiBa Study group, Journal of Neurology, 2021, https://doi.org/10.1007/s00415-021-10554-1
A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response
Lainšček D., Fink T., Forstnerič V., Hafner-Bratkovič I., Orehek S., Strmšek Z., Manček-Keber M., Pečan P., Esih H., Malenšek Š., Aupič J., Dekleva P., Plaper T., Vidmar S., Kadunc L., Benčina M., Omersa N., Anderluh N., Pojer F., Lau K., Hacker D., Correia B.E., Peterhoff D., Wagner R., Bergant W., Herrmann A., Pichlmair A., Jerala R., 2021, Vaccines, 9(5), 431; https://doi.org/10.3390/vaccines9050431
Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19
Dugas M, Grote-Westrick T, Merle U, Fontenay M, Kremer AE, Hanses F, Vollenberg R, Lorentzen E, Tiwari-Heckler S, Duchemin J, Ellouze S, Vetter M, Fürst J, Schuster P, Brix T, Denkinger CM, Müller-Tidow C, Schmidt H, Tepasse PR, Kühn J.. J Clin Virol 2021 Apr 24, 104847 (in press).
The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study
De Pellegrin ML, Rohrhofer A, Schuster P, Schmidt B, Peterburs P, Gessner A.. Clinical Phytoscience. 2021 Mar 7: 29.
ECMO in COVID-19 – prolonged therapy needed? A retrospective analysis of outcome and prognostic factors.
Perfusion. 2021 Feb 20:267659121995997. doi: 10.1177/0267659121995997.
Coronavirus disease 2019 induces multi-lineage morphologic changes in peripheral blood cells.
EJHaem. 2020 Jun 29:10.1002/jha2.44. doi: 10.1002/jha2.44.
A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2.
Clin Oral Investig. 2020 Oct;24(10):3707-3713. doi: 10.1007/s00784-020-03549-1.
Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2
Hitzenbichler F., Bauernfeind S., Salzberger B., Schmidt B., Wenzel J.J. Viruses 2021 https://doi.org/10.3390/v13040653
Evaluation of a Broad Panel of SARS-CoV-2 Serological Tests for Diagnostic Use
Werner, M.; Pervan, P.; Glck, V.; Zeman, F.; Koller, M.; Burkhardt, R.; Glck, T.; Wenzel, J.J.; Schmidt, B.; Gessner, A.; Peterhoff, D. J. Clin. Med. 2021, 10, 1580. https://doi.org/10.3390/jcm10081580
SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19
Vivian Glück, Sonja Grobecker, Leonid Tydykov, Bernd Salzberger, Thomas Glück, Tanja Weidlich, Manuela Bertok, Christine Gottwald, Jürgen J. Wenzel, André Gessner, Barbara Schmidt & David Peterhoff, 2021, Infection, https://doi.org/10.1007/s15010-021-01598-6