Aktueller Stand 14.12.2023: 61 Publikationen zur Coronavirus-Forschung wurden unter Beteiligung des Instituts für Mikrobiologie und Hygiene bislang veröffentlicht:
Clinical and immunological benefits of full primary COVID-19 vaccination in individuals with SARS-CoV-2 breakthrough infections: A prospective cohort study in non-hospitalized adults.
Prelog M, Jeske SD, Asam C, Fuchs A, Wieser A, Gall C, Wytopil M, Mueller-Schmucker SM, Beileke S, Goekkaya M, Kling E, Geldmacher C, Rubio-Acero R, Plank M, Christa C, Willmann A, Vu M, Einhauser S, Weps M, Lampl BMJ, Almanzar G, Kousha K, Schwägerl V, Liebl B, Weber B, Drescher J, Scheidt J, Gefeller O, Messmann H, Protzer U, Liese J, Hoelscher M, Wagner R, Überla K, Steininger P; CoVaKo Study Group.
J Clin Virol. 2023 Nov 28;170:105622. doi: 10.1016/j.jcv.2023.105622. Online ahead of print.PMID: 38091664
Population-based study of the durability of humoral immunity after SARS-CoV-2 infection.
Peterhoff D, Wiegrebe S, Einhauser S, Patt AJ, Beileke S, Günther F, Steininger P, Niller HH, Burkhardt R, Küchenhoff H, Gefeller O, Überla K, Heid IM, Wagner R.
Front Immunol. 2023 Oct 5;14:1242536. doi: 10.3389/fimmu.2023.1242536. eCollection 2023.PMID: 37868969
A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses.
Vishwanath S, Carnell GW, Ferrari M, Asbach B, Billmeier M, George C, Sans MS, Nadesalingam A, Huang CQ, Paloniemi M, Stewart H, Chan A, Wells DA, Neckermann P, Peterhoff D, Einhauser S, Cantoni D, Neto MM, Jordan I, Sandig V, Tonks P, Temperton N, Frost S, Sohr K, Ballesteros MTL, Arbabi F, Geiger J, Dohmen C, Plank C, Kinsley R, Wagner R, Heeney JL.
Nat Biomed Eng. 2023 Sep 25. doi: 10.1038/s41551-023-01094-2. Online ahead of print.PMID: 37749309
Efficacy of a Mouthwash Containing CHX and CPC in SARS-CoV-2-Positive Patients: A Randomized Controlled Clinical Trial.
Bonn EL, Rohrhofer A, Audebert FX, Lang H, Auer DL, Scholz KJ, Schuster P, Wenzel JJ, Hiller KA, Buchalla W, Gottsauner JM, Vielsmeier V, Schmidt B, Cieplik F.
J Dent Res. 2023 Mar 21:220345231156415. doi: 10.1177/00220345231156415. Online ahead of print.PMID: 36942423
Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants.
Carnell GW, Billmeier M, Vishwanath S, Suau Sans M, Wein H, George CL, Neckermann P, Del Rosario JMM, Sampson AT, Einhauser S, Aguinam ET, Ferrari M, Tonks P, Nadesalingam A, Schütz A, Huang CQ, Wells DA, Paloniemi M, Jordan I, Cantoni D, Peterhoff D, Asbach B, Sandig V, Temperton N, Kinsley R, Wagner R, Heeney JL.
Front Immunol. 2023 Feb 23;14:1118523. doi: 10.3389/fimmu.2023.1118523. eCollection 2023.PMID: 36911730 Free PMC article.
Higher Infection Risk among Health Care Workers and Lower Risk among Smokers Persistent across SARS-CoV-2 Waves-Longitudinal Results from the Population-Based TiKoCo Seroprevalence Study.
Günther F, Einhauser S, Peterhoff D, Wiegrebe S, Niller HH, Beileke S, Steininger P, Burkhardt R, Küchenhoff H, Gefeller O, Überla K, Heid IM, Wagner R.
Int J Environ Res Public Health. 2022 Dec 17;19(24):16996. doi: 10.3390/ijerph192416996.PMID: 36554876
Vaccination and protective immunity to SARS-CoV-2 omicron variants in people with immunodeficiencies.
Nadesalingam A, Cantoni D, Aguinam ET, Chan AC, Paloniemi M, Ohlendorf L, George C, Carnell G, Lyall J, Ferrari M, Temperton N, Wagner R, Castillo-Olivares J, Baxendale H, Heeney JL.
Lancet Microbe. 2022 Nov 1:S2666-5247(22)00297-X. doi: 10.1016/S2666-5247(22)00297-X. Online ahead of print.PMID: 36332646
Association between Adverse Reactions and Humoral Immune Response No Longer Detectable after BNT162b2 Booster Vaccination
Bauernfeind S, Einhauser S, Tydykov L, Mader AL, Salzberger V, Hitzenbichler F, Mohr A, Burkhardt R, Wagner R, Peterhoff D
Vaccines 2022, 10, 1608. https://doi.org/10.3390/vaccines10101608
SARS-CoV-2 Vaccine Against Virus: Mission accomplished!?
Magnus CL, Schmidt B. In: S. Adibi et al. (eds.),
Frontiers of COVID-19: Scientific and Clinical Aspects of the Novel Coronavirus 2019. Springer Nature 2022. https://doi.org/10.1007/978-3-031-08045-6_27.
CLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry.
Heinl ES, Lorenz S, Schmidt B, Nasser M Laqtom N, Mazzulli JR, Francelle L, Yu TW, Greenberg B, Storch S, Tegtmeier I, Othmen H, Maurer K, Steinfurth M, Witzgall R, Milenkovic V, Wetzel CH, Reichold M.
iScience. 2022 Oct 21;25(10):105082. doi: 10.1016/j.isci.2022.105082.
Stellenwert der COVID-19-Impfung im Kontext von Long-COVID [The value of COVID-19 vaccination in the context of Long-COVID]
Bauernfeind S, Schmidt B.
Inn Med (Heidelb). 2022 Aug;63(8):840-850. German. doi: 10.1007/s00108-022-01368-y. Epub 2022 Jul 7.
Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab
Magnus CL, Hiergeist A, Schuster P, Rohrhofer A, Medenbach J, Gessner A, Peterhoff D, Schmidt B
Front. Immunol. 2022 Aug 24 doi:10.3389/fimmu.2022.966236
Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany.
Einhauser S, Peterhoff D, Beileke S, Günther F, Niller HH, Steininger P, Knöll A, Korn K, Berr M, Schütz A, Wiegrebe S, Stark KJ, Gessner A, Burkhardt R, Kabesch M, Schedl H, Küchenhoff H, Pfahlberg AB, Heid IM, Gefeller O, Überla K, Wagner R.
Viruses. 2022 May 27;14(6):1168. doi: 10.3390/v14061168.PMID: 35746640
Mouthrinses against SARS-CoV-2 – high antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial.
Meister TL, Gottsauner JM, Schmidt B, Heinen N, Todt D, Audebert F, Buder F, Lang H, Gessner A, Steinmann E, Vielsmeier V, Pfaender S, Cieplik F.
Virus Res. 2022 Apr 30:198791. doi: 10.1016/j.virusres.2022.198791. Online ahead of print.PMID: 35504446
Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19-convalescent subjects
Vivian Glück, Leonid Tydykov, Anna-Lena Mader, Anne-Sophie Warda, Manuela Bertok, Tanja Weidlich, Christine Gottwald, Josef Köstler, Bernd Salzberger, Ralf Wagner, Michael Koller, André Gessner, Barbara Schmidt, Thomas Glück & David Peterhoff
Infection (2022)2022). https://doi.org/10.1007/s15010-022-01817-8
Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds.
Cantoni D, Mayora-Neto M, Nadesalingam A, Wells DA, Carnell GW, Ohlendorf L, Ferrari M, Palmer P, Chan ACY, Smith P, Bentley EM, Einhauser S, Wagner R, Page M, Raddi G, Baxendale H, Castillo-Olivares J, Heeney J, Temperton N.
Front Immunol. 2022 Mar 7;13:773982. doi: 10.3389/fimmu.2022.773982. eCollection 2022.PMID: 35330908 Free PMC article.
Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection.
Hintschich CA, Fischer R, Hummel T, Wenzel JJ, Bohr C, Vielsmeier V.
PLoS One. 2022 Mar 23;17(3):e0265686. doi: 10.1371/journal.pone.0265686. eCollection 2022.PMID: 35320821
Omicron’s binding to Sotrovimab, Casirivimab, Imdevimab, CR3022, and sera from previously infected or vaccinated individuals.
Mader AL, Tydykov L, Glück V, Bertok M, Weidlich T, Gottwald C, Stefl A, Vogel M, Plentz A, Köstler J, Salzberger B, Wenzel JJ, Niller HH, Jantsch J, Wagner R, Schmidt B, Glück T, Gessner A, Peterhoff D.
iScience. 2022 Mar 14:104076. doi: 10.1016/j.isci.2022.104076. Online ahead of print.PMID: 35309727 Free PMC article.
Comparative Immunogenicity of COVID-19 Vaccines in a Population-Based Cohort Study with SARS-CoV-2-Infected and Uninfected Participants.
Peterhoff D, Einhauser S, Beileke S, Niller HH, Günther F, Schachtner M, Asbach B, Steininger P, Tenbusch M, Peter AS, Gessner A, Burkhardt R, Heid IM, Wagner R, Überla K.
Vaccines (Basel). 2022 Feb 18;10(2):324. doi: 10.3390/vaccines10020324.PMID: 35214782
Gustatory Function in Acute COVID-19 – Results from Home-Based Psychophysical Testing.
Hintschich CA, Brosig A, Hummel T, Andorfer KE, Wenzel JJ, Bohr C, Vielsmeier V.
Laryngoscope. 2022 Feb 21. doi: 10.1002/lary.30080. Online ahead of print.PMID: 35188975
Niedrige Inzidenz von SARS-CoV-2-Infektionen bei Krankenhausmitarbeitern eines Maximalversorgers
Ergebnisse einer prospektiven serologischen Kohortenstudie der ersten und zweiten COVID-19-Welle
Hupf J., Burkhardt R., ·Gessner A., Maier-Stocker, C., Zimmermann M., Hanses F., ·Peterhoff D.
Med Klin Intensivmed Notfmed https://doi.org/10.1007/s00063-021-00890-51
Neutralization of SARS-CoV-2 Delta variant is increased after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination.
Bauswein M, Peterhoff D, Plentz A, Hiergeist A, Wagner R, Gessner A, Salzberger B, Schmidt B, Bauernfeind S.
iScience. 2022 Jan 5:103694. doi: 10.1016/j.isci.2021.103694. Online ahead of print.PMID: 35013723 Free PMC article.
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Valero J, Civit L, Dupont DM, Selnihhin D, Reinert LS, Idorn M, Israels BA, Bednarz AM, Bus C, Asbach B, Peterhoff D, Pedersen FS, Birkedal V, Wagner R, Paludan SR, Kjems J.
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2112942118. doi: 10.1073/pnas.2112942118.PMID: 34876524
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases.
Castillo-Olivares J, Wells DA, Ferrari M, Chan ACY, Smith P, Nadesalingam A, Paloniemi M, Carnell GW, Ohlendorf L, Cantoni D, Mayora-Neto M, Palmer P, Tonks P, Temperton NJ, Peterhoff D, Neckermann P, Wagner R, Doffinger R, Kempster S, Otter AD, Semper A, Brooks T, Albecka A, James LC, Page M, Schwaeble W, Baxendale H, Heeney JL.
Front Immunol. 2021 Nov 19;12:748291. doi: 10.3389/fimmu.2021.748291. eCollection 2021.PMID: 34867975 Free PMC article.
Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone.
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K.
J Clin Invest. 2021 Nov 15;131(22):e148225. doi: 10.1172/JCI148225.PMID: 34779418
Symptoms, SARS-CoV-2 Antibodies, and Neutralization Capacity in a Cross Sectional-Population of German Children.
Laub O, Leipold G, Toncheva AA, Peterhoff D, Einhauser S, Neckermann P, Borchers N, Santos-Valente E, Kheiroddin P, Buntrock-Döpke H, Laub S, Schöberl P, Schweiger-Kabesch A, Ewald D, Horn M, Niggel J, Ambrosch A, Überla K, Gerling S, Brandstetter S, Wagner R, Kabesch M; Corona Virus Antibodies in Children from Bavaria (CoKiBa) Study Group.
Front Pediatr. 2021 Oct 4;9:678937. doi: 10.3389/fped.2021.678937. eCollection 2021.PMID: 34671582
SARS-CoV-2 transmission during an indoor professional sporting event.
Pauser J, Schwarz C, Morgan J, Jantsch J, Brem M.
Sci Rep. 2021 Oct 20;11(1):20723. doi: 10.1038/s41598-021-99997-0.PMID: 34671096
Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2.
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D.
Vaccines (Basel). 2021 Sep 27;9(10):1089. doi: 10.3390/vaccines9101089.PMID: 34696197
Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients.
de Castilhos J, Zamir E, Hippchen T, Rohrbach R, Schmidt S, Hengler S, Schumacher H, Neubauer M, Kunz S, Müller-Esch T, Hiergeist A, Gessner A, Khalid D, Gaiser R, Cullin N, Papagiannarou SM, Beuthien-Baumann B, Krämer A, Bartenschlager R, Jäger D, Müller M, Herth F, Duerschmied D, Schneider J, Schmid RM, Eberhardt JF, Khodamoradi Y, Vehreschild MJGT, Teufel A, Ebert MP, Hau P, Salzberger B, Schnitzler P, Poeck H, Elinav E, Merle U, Stein-Thoeringer CK.
Clin Infect Dis. 2021 Oct 25:ciab902. doi: 10.1093/cid/ciab902. Online ahead of print.PMID: 34694375
Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests-A Population-Based Evaluation.
Einhauser S, Peterhoff D, Niller HH, Beileke S, Günther F, Steininger P, Burkhardt R, Heid IM, Pfahlberg AB, Überla K, Gefeller O, Wagner R.
Diagnostics (Basel). 2021 Oct 6;11(10):1843. doi: 10.3390/diagnostics11101843.PMID: 34679541 Free PMC article.
Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.
Glück V, Grobecker S, Köstler J, Tydykov L, Bertok M, Weidlich T, Gottwald C, Salzberger B, Wagner R, Zeman F, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D.
Infection. 2021 Sep 25. doi: 10.1007/s15010-021-01703-9. Online ahead of print.PMID: 34562263
Association between reactogenicity and immunogenicity after vaccination with BNT162b2
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D.
Vaccines, received 4 August 21, accepted for publication
Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses.
Sampson AT, Heeney J, Cantoni D, Ferrari M, Sans MS, George C, Di Genova C, Mayora Neto M, Einhauser S, Asbach B, Wagner R, Baxendale H, Temperton N, Carnell G.
Viruses. 2021 Aug 10;13(8):1579. doi: 10.3390/v13081579.PMID: 34452443
Buder F, Bauswein M, Magnus CL, Audebert F, Lang H, Kundel C, Distler K, Reuschel E, Lubnow M, Müller T, Lunz D, Graf B, Schmid S, Müller M, Poeck H, Hanses F, Salzberger B, Peterhoff D, Wenzel J.J., Schmidt B, Lampl BMJ.
Nadesalingam A, Cantoni D, Wells DA, Aguinam ET, Ferrari M, Smith P, Chan A, Carnell G, Ohlendorf L, Einhauser S, George C, Wagner R, Temperton N, Castillo-Olivares J, Baxendale H, Heeney JL; HICC consortium.
Bauernfeind S, Hitzenbichler F, Huppertz G, Zeman F, Koller M, Schmidt B, Plentz A, Bauswein M, Mohr A, Salzberger B.
Infection. 2021 May 20:1–5.
Estimates and determinants of SARS-CoV-2 seroprevalence and infection fatality ratio using latent class analysis: the population-based Tirschenreuth study in the hardest-hit German county in spring 2020
Wagner R., Peterhoff D., Beileke S., Guenther D., Berr M., Einhauser S., Schuetz A., Niller H.H., Steininger P., Knoell A., Tenbusch M., Maier C., Korn K., Stark K., Gessner A., Burkhardt R., Kabesch M., Schedl H., Küchenhoff H., Pfahlberg A., Heid I., Gefeller O., Überla K.; MDPI Viruses, 2021 doi:10.1101/2021.03.29.21254343
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Renner K, Schwittay T, Chaabane S, Gottschling J, Müller C, Tiefenböck C, Salewski JN, Winter F, Buchtler S, Balam S, Malfertheiner MV, Lubnow M, Lunz D, Graf B, Hitzenbichler F, Hanses F, Poeck H, Kreutz M, Orsó E, Burkhardt R, Niedermair T, Brochhausen C, Gessner A, Salzberger B, Mack M.
Nat Commun. 2021 May 21;12(1):3006. doi: 10.1038/s41467-021-23334-2.
Pooling for SARS-CoV-2-testing: comparison of three commercially available RT-qPCR kits in an experimental approach
Cibali E, Wenzel JJ, Gruber R, Ambrosch A;
Chem Lab Med 2021, 59(6):e243-e245.
Psychophysical tests reveal impaired olfaction but preserved gustation in COVID-19 patients
Hintschich CA, Wenzel JJ, Hummel T, Hankir MK, Kühnel T, Vielsmeier V, Bohr C.
Int Forum Allergy Rhinol 2020, 10(9):1105-1107.
SARS-CoV-2 spike protein stabilized in the closed state induces potent neutralizing responses.
Carnell GW, Ciazynska KA, Wells DA, Xiong X, Aguinam ET, McLaughlin SH, Mallery D, Ebrahimi S, Ceron-Gutierrez L, Asbach B, Einhauser S, Wagner R, James LC, Doffinger R, Heeney JL, Briggs JAG.
J Virol. 2021 May 7:JVI.00203-21. doi: 10.1128/JVI.00203-21. Online ahead of print.PMID: 33963055
Serum neurofilament light chain (sNfL) values in a large cross‑sectional population of children with asymptomatic to moderate COVID‑19
Geis T.,·Brandstetter S., Toncheva A.A., Laub O., Leipold G., ·Wagner R., Kabesch M., Kasser S., Kuhle J., Wellmann S.,· CoKiBa Study group, Journal of Neurology, 2021, https://doi.org/10.1007/s00415-021-10554-1
A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response
Lainšček D., Fink T., Forstnerič V., Hafner-Bratkovič I., Orehek S., Strmšek Z., Manček-Keber M., Pečan P., Esih H., Malenšek Š., Aupič J., Dekleva P., Plaper T., Vidmar S., Kadunc L., Benčina M., Omersa N., Anderluh N., Pojer F., Lau K., Hacker D., Correia B.E., Peterhoff D., Wagner R., Bergant W., Herrmann A., Pichlmair A., Jerala R., 2021,
Vaccines, 9(5), 431; https://doi.org/10.3390/vaccines9050431
Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19
Dugas M, Grote-Westrick T, Merle U, Fontenay M, Kremer AE, Hanses F, Vollenberg R, Lorentzen E, Tiwari-Heckler S, Duchemin J, Ellouze S, Vetter M, Fürst J, Schuster P, Brix T, Denkinger CM, Müller-Tidow C, Schmidt H, Tepasse PR, Kühn J..
J Clin Virol 2021 Apr 24, 104847 (in press).
The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study
De Pellegrin ML, Rohrhofer A, Schuster P, Schmidt B, Peterburs P, Gessner A.. Clinical Phytoscience. 2021 Mar 7: 29.
ECMO in COVID-19 – prolonged therapy needed? A retrospective analysis of outcome and prognostic factors.
Perfusion. 2021 Feb 20:267659121995997. doi: 10.1177/0267659121995997.
Coronavirus disease 2019 induces multi-lineage morphologic changes in peripheral blood cells.
EJHaem. 2020 Jun 29:10.1002/jha2.44. doi: 10.1002/jha2.44.
A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2.
Clin Oral Investig. 2020 Oct;24(10):3707-3713. doi: 10.1007/s00784-020-03549-1.
Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2
Hitzenbichler F., Bauernfeind S., Salzberger B., Schmidt B., Wenzel J.J. Viruses 2021 https://doi.org/10.3390/v13040653
Evaluation of a Broad Panel of SARS-CoV-2 Serological Tests for Diagnostic Use
Werner, M.; Pervan, P.; Glck, V.; Zeman, F.; Koller, M.; Burkhardt, R.; Glck, T.; Wenzel, J.J.; Schmidt, B.; Gessner, A.; Peterhoff, D. J. Clin. Med. 2021, 10, 1580. https://doi.org/10.3390/jcm10081580
SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19
Vivian Glück, Sonja Grobecker, Leonid Tydykov, Bernd Salzberger, Thomas Glück, Tanja Weidlich, Manuela Bertok, Christine Gottwald, Jürgen J. Wenzel, André Gessner, Barbara Schmidt & David Peterhoff, 2021, Infection, https://doi.org/10.1007/s15010-021-01598-6