Publikationen zum Coronavirus mit Institutsbeteiligung

Aktueller Stand 04.05.22:  47 Publikationen zur Coronavirus-Forschung  wurden unter Beteiligung des Instituts für Mikrobiologie und Hygiene bislang veröffentlicht:

Mouthrinses against SARS-CoV-2 – high antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial.
Meister TL, Gottsauner JM, Schmidt B, Heinen N, Todt D, Audebert F, Buder F, Lang H, Gessner A, Steinmann E, Vielsmeier V, Pfaender S, Cieplik F.
Virus Res. 2022 Apr 30:198791. doi: 10.1016/j.virusres.2022.198791. Online ahead of print.PMID: 35504446

Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19-convalescent subjects
Vivian Glück, Leonid Tydykov, Anna-Lena Mader, Anne-Sophie Warda, Manuela Bertok, Tanja Weidlich, Christine Gottwald, Josef Köstler, Bernd Salzberger, Ralf Wagner, Michael Koller, André Gessner, Barbara Schmidt, Thomas Glück & David Peterhoff
Infection (2022)2022).

Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds.
Cantoni D, Mayora-Neto M, Nadesalingam A, Wells DA, Carnell GW, Ohlendorf L, Ferrari M, Palmer P, Chan ACY, Smith P, Bentley EM, Einhauser S, Wagner R, Page M, Raddi G, Baxendale H, Castillo-Olivares J, Heeney J, Temperton N.
Front Immunol. 2022 Mar 7;13:773982. doi: 10.3389/fimmu.2022.773982. eCollection 2022.PMID: 35330908 Free PMC article.

Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection.
Hintschich CA, Fischer R, Hummel T, Wenzel JJ, Bohr C, Vielsmeier V.
PLoS One. 2022 Mar 23;17(3):e0265686. doi: 10.1371/journal.pone.0265686. eCollection 2022.PMID: 35320821

Omicron’s binding to Sotrovimab, Casirivimab, Imdevimab, CR3022, and sera from previously infected or vaccinated individuals.
Mader AL, Tydykov L, Glück V, Bertok M, Weidlich T, Gottwald C, Stefl A, Vogel M, Plentz A, Köstler J, Salzberger B, Wenzel JJ, Niller HH, Jantsch J, Wagner R, Schmidt B, Glück T, Gessner A, Peterhoff D.
iScience. 2022 Mar 14:104076. doi: 10.1016/j.isci.2022.104076. Online ahead of print.PMID: 35309727 Free PMC article.

Comparative Immunogenicity of COVID-19 Vaccines in a Population-Based Cohort Study with SARS-CoV-2-Infected and Uninfected Participants.
Peterhoff D, Einhauser S, Beileke S, Niller HH, Günther F, Schachtner M, Asbach B, Steininger P, Tenbusch M, Peter AS, Gessner A, Burkhardt R, Heid IM, Wagner R, Überla K.
Vaccines (Basel). 2022 Feb 18;10(2):324. doi: 10.3390/vaccines10020324.PMID: 35214782

Gustatory Function in Acute COVID-19 – Results from Home-Based Psychophysical Testing.
Hintschich CA, Brosig A, Hummel T, Andorfer KE, Wenzel JJ, Bohr C, Vielsmeier V.
Laryngoscope. 2022 Feb 21. doi: 10.1002/lary.30080. Online ahead of print.PMID: 35188975

Niedrige Inzidenz von SARS-CoV-2-Infektionen bei Krankenhausmitarbeitern eines Maximalversorgers
Ergebnisse einer prospektiven serologischen Kohortenstudie der ersten und zweiten COVID-19-Welle
Hupf J., Burkhardt R., ·Gessner A., Maier-Stocker, C., Zimmermann M., Hanses F., ·Peterhoff D.
Med Klin Intensivmed Notfmed

Neutralization of SARS-CoV-2 Delta variant is increased after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination.
Bauswein M, Peterhoff D, Plentz A, Hiergeist A, Wagner R, Gessner A, Salzberger B, Schmidt B, Bauernfeind S.
iScience. 2022 Jan 5:103694. doi: 10.1016/j.isci.2021.103694. Online ahead of print.PMID: 35013723 Free PMC article.

A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Valero J, Civit L, Dupont DM, Selnihhin D, Reinert LS, Idorn M, Israels BA, Bednarz AM, Bus C, Asbach B, Peterhoff D, Pedersen FS, Birkedal V, Wagner R, Paludan SR, Kjems J.
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2112942118. doi: 10.1073/pnas.2112942118.PMID: 34876524

Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases.
Castillo-Olivares J, Wells DA, Ferrari M, Chan ACY, Smith P, Nadesalingam A, Paloniemi M, Carnell GW, Ohlendorf L, Cantoni D, Mayora-Neto M, Palmer P, Tonks P, Temperton NJ, Peterhoff D, Neckermann P, Wagner R, Doffinger R, Kempster S, Otter AD, Semper A, Brooks T, Albecka A, James LC, Page M, Schwaeble W, Baxendale H, Heeney JL.
Front Immunol. 2021 Nov 19;12:748291. doi: 10.3389/fimmu.2021.748291. eCollection 2021.PMID: 34867975 Free PMC article.

Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone.
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K.
J Clin Invest. 2021 Nov 15;131(22):e148225. doi: 10.1172/JCI148225.PMID: 34779418

Symptoms, SARS-CoV-2 Antibodies, and Neutralization Capacity in a Cross Sectional-Population of German Children.
Laub O, Leipold G, Toncheva AA, Peterhoff D, Einhauser S, Neckermann P, Borchers N, Santos-Valente E, Kheiroddin P, Buntrock-Döpke H, Laub S, Schöberl P, Schweiger-Kabesch A, Ewald D, Horn M, Niggel J, Ambrosch A, Überla K, Gerling S, Brandstetter S, Wagner R, Kabesch M; Corona Virus Antibodies in Children from Bavaria (CoKiBa) Study Group.
Front Pediatr. 2021 Oct 4;9:678937. doi: 10.3389/fped.2021.678937. eCollection 2021.PMID: 34671582

SARS-CoV-2 transmission during an indoor professional sporting event.
Pauser J, Schwarz C, Morgan J, Jantsch J, Brem M.
Sci Rep. 2021 Oct 20;11(1):20723. doi: 10.1038/s41598-021-99997-0.PMID: 34671096

Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2.
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D.
Vaccines (Basel). 2021 Sep 27;9(10):1089. doi: 10.3390/vaccines9101089.PMID: 34696197

Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients.
de Castilhos J, Zamir E, Hippchen T, Rohrbach R, Schmidt S, Hengler S, Schumacher H, Neubauer M, Kunz S, Müller-Esch T, Hiergeist A, Gessner A, Khalid D, Gaiser R, Cullin N, Papagiannarou SM, Beuthien-Baumann B, Krämer A, Bartenschlager R, Jäger D, Müller M, Herth F, Duerschmied D, Schneider J, Schmid RM, Eberhardt JF, Khodamoradi Y, Vehreschild MJGT, Teufel A, Ebert MP, Hau P, Salzberger B, Schnitzler P, Poeck H, Elinav E, Merle U, Stein-Thoeringer CK.
Clin Infect Dis. 2021 Oct 25:ciab902. doi: 10.1093/cid/ciab902. Online ahead of print.PMID: 34694375

Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests-A Population-Based Evaluation.
Einhauser S, Peterhoff D, Niller HH, Beileke S, Günther F, Steininger P, Burkhardt R, Heid IM, Pfahlberg AB, Überla K, Gefeller O, Wagner R.
Diagnostics (Basel). 2021 Oct 6;11(10):1843. doi: 10.3390/diagnostics11101843.PMID: 34679541 Free PMC article.

Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.
Glück V, Grobecker S, Köstler J, Tydykov L, Bertok M, Weidlich T, Gottwald C, Salzberger B, Wagner R, Zeman F, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D.
Infection. 2021 Sep 25. doi: 10.1007/s15010-021-01703-9. Online ahead of print.PMID: 34562263

Association between reactogenicity and immunogenicity after vaccination with BNT162b2
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D.
Vaccines, received 4 August 21, accepted for publication

Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses.
Sampson AT, Heeney J, Cantoni D, Ferrari M, Sans MS, George C, Di Genova C, Mayora Neto M, Einhauser S, Asbach B, Wagner R, Baxendale H, Temperton N, Carnell G.
Viruses. 2021 Aug 10;13(8):1579. doi: 10.3390/v13081579.PMID: 34452443

SARS-CoV-2 infectivity correlates with high viral loads and detection of viral antigen and is terminated by seroconversion.
Buder F, Bauswein M, Magnus CL, Audebert F, Lang H, Kundel C, Distler K, Reuschel E, Lubnow M, Müller T, Lunz D, Graf B, Schmid S, Müller M, Poeck H, Hanses F, Salzberger B, Peterhoff D, Wenzel J.J., Schmidt B, Lampl BMJ.  J Infect Dis. 2021 Aug 24:jiab415. doi: 10.1093/infdis/jiab415. Online ahead of print.

Paucity and discordance of neutralising antibody responses to SARS-CoV-2 VOCs in vaccinated immunodeficient patients and health-care workers in the UK.
Nadesalingam A, Cantoni D, Wells DA, Aguinam ET, Ferrari M, Smith P, Chan A, Carnell G, Ohlendorf L, Einhauser S, George C, Wagner R, Temperton N, Castillo-Olivares J, Baxendale H, Heeney JL; HICC consortium. Lancet Microbe. 2021 Jun 28. doi: 10.1016/S2666-5247(21)00157-9. Online ahead of print.PMID: 34223399 Free PMC article.

Brief report: attitudes towards Covid-19 vaccination among hospital employees in a tertiary care university hospital in Germany in December 2020.
Bauernfeind S, Hitzenbichler F, Huppertz G, Zeman F, Koller M, Schmidt B, Plentz A, Bauswein M, Mohr A, Salzberger B. Infection. 2021 May 20:1–5.

Estimates and determinants of SARS-CoV-2 seroprevalence and infection fatality ratio using latent class analysis: the population-based Tirschenreuth study in the hardest-hit German county in spring 2020
Wagner R., Peterhoff D., Beileke S., Guenther D., Berr M., Einhauser S., Schuetz A., Niller H.H., Steininger P., Knoell A., Tenbusch M., Maier C., Korn K., Stark K., Gessner A., Burkhardt R., Kabesch M., Schedl H., Küchenhoff H., Pfahlberg A., Heid I., Gefeller O., Überla K.; MDPI Viruses, 2021 doi:10.1101/2021.03.29.21254343

Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Renner K, Schwittay T, Chaabane S, Gottschling J, Müller C, Tiefenböck C, Salewski JN, Winter F, Buchtler S, Balam S, Malfertheiner MV, Lubnow M, Lunz D, Graf B, Hitzenbichler F, Hanses F, Poeck H, Kreutz M, Orsó E, Burkhardt R, Niedermair T, Brochhausen C, Gessner A, Salzberger B, Mack M. Nat Commun. 2021 May 21;12(1):3006. doi: 10.1038/s41467-021-23334-2.

Pooling for SARS-CoV-2-testing: comparison of three commercially available RT-qPCR kits in an experimental approach
Cibali E, Wenzel JJ, Gruber R, Ambrosch A; Chem Lab Med 2021, 59(6):e243-e245.

Psychophysical tests reveal impaired olfaction but preserved gustation in COVID-19 patients
Hintschich CA, Wenzel JJ, Hummel T, Hankir MK, Kühnel T, Vielsmeier V, Bohr C. Int Forum Allergy Rhinol 2020, 10(9):1105-1107.

SARS-CoV-2 spike protein stabilized in the closed state induces potent neutralizing responses.
Carnell GW, Ciazynska KA, Wells DA, Xiong X, Aguinam ET, McLaughlin SH, Mallery D, Ebrahimi S, Ceron-Gutierrez L, Asbach B, Einhauser S, Wagner R, James LC, Doffinger R, Heeney JL, Briggs JAG. J Virol. 2021 May 7:JVI.00203-21. doi: 10.1128/JVI.00203-21. Online ahead of print.PMID: 33963055

Serum neurofilament light chain (sNfL) values in a large cross‑sectional population of children with asymptomatic to moderate COVID‑19
Geis T.,·Brandstetter S., Toncheva A.A., Laub O., Leipold G., ·Wagner R., Kabesch M., Kasser S., Kuhle J., Wellmann S.,· CoKiBa Study group, Journal of Neurology, 2021,

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response
Lainšček D., Fink T., Forstnerič V., Hafner-Bratkovič I., Orehek S., Strmšek Z., Manček-Keber M., Pečan P., Esih H., Malenšek Š., Aupič J., Dekleva P., Plaper T., Vidmar S., Kadunc L., Benčina M., Omersa N., Anderluh N., Pojer F., Lau K., Hacker D., Correia B.E., Peterhoff D., Wagner R., Bergant W., Herrmann A.,  Pichlmair A., Jerala R., 2021, Vaccines, 9(5), 431;

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19
Dugas M, Grote-Westrick T, Merle U, Fontenay M, Kremer AE, Hanses F, Vollenberg R, Lorentzen E, Tiwari-Heckler S, Duchemin J, Ellouze S, Vetter M, Fürst J, Schuster P, Brix T, Denkinger CM, Müller-Tidow C, Schmidt H, Tepasse PR, Kühn J.. J Clin Virol 2021 Apr 24, 104847 (in press).

The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study
De Pellegrin ML, Rohrhofer A, Schuster P, Schmidt B, Peterburs P, Gessner A.. Clinical Phytoscience. 2021 Mar 7: 29.

ECMO in COVID-19 – prolonged therapy needed? A retrospective analysis of outcome and prognostic factors.
Dreier E, Malfertheiner MV, Dienemann T, Fisser C, Foltan M, Geismann F, Graf B, Lunz D, Maier LS, Müller T, Offner R, Peterhoff D, Philipp A, Salzberger B, Schmidt B, Sinner B, Lubnow M. Perfusion. 2021 Feb 20:267659121995997. doi: 10.1177/0267659121995997.

Coronavirus disease 2019 induces multi-lineage morphologic changes in peripheral blood cells.
Lüke F, Orsó E, Kirsten J, Poeck H, Grube M, Wolff D, Burkhardt R, Lunz D, Lubnow M, Schmidt B, Hitzenbichler F, Hanses F, Salzberger B, Evert M, Herr W, Brochhausen C, Pukrop T, Reichle A, Heudobler D. EJHaem. 2020 Jun 29:10.1002/jha2.44. doi: 10.1002/jha2.44.

A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2.
Gottsauner MJ, Michaelides I, Schmidt B, Scholz KJ, Buchalla W, Widbiller M, Hitzenbichler F, Ettl T, Reichert TE, Bohr C, Vielsmeier V, Cieplik F. Clin Oral Investig. 2020 Oct;24(10):3707-3713. doi: 10.1007/s00784-020-03549-1.

Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2
Hitzenbichler F., Bauernfeind S., Salzberger B., Schmidt B., Wenzel J.J. Viruses 2021

Evaluation of a Broad Panel of SARS-CoV-2 Serological Tests for Diagnostic Use
Werner, M.; Pervan, P.; Glck, V.; Zeman, F.; Koller, M.; Burkhardt, R.; Glck, T.; Wenzel, J.J.; Schmidt, B.; Gessner, A.; Peterhoff, D. J. Clin. Med. 2021, 10, 1580.

SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19
Vivian Glück, Sonja Grobecker, Leonid Tydykov, Bernd Salzberger, Thomas Glück, Tanja Weidlich, Manuela Bertok, Christine Gottwald, Jürgen J. Wenzel, André Gessner, Barbara Schmidt & David Peterhoff, 2021, Infection,

Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation
Katja Evert, Thomas Dienemann, Christoph Brochhausen,  Dirk Lunz,  Matthias Lubnow, Markus Ritzka, Felix Keil, Matthias Trummer, Alexander Scheiter, Bernd Salzberger, Udo Reischl Peter Boor, André Gessner, Jonathan Jantsch, Diego F. Calvisi, Matthias Evert,  Barbara Schmidt, Michaela Simon, 2021, Virchows Arch,

Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality
Hähnel, V.; Peterhoff, D.; Bäuerlein. V.; Brosig, A-M.; Pamler, I.; Johnson, C.; Bica, A.; Totir, M.; Ossner, T.; Stemmer, B.; Toelge, M.; Schütz, A.; Niller H.H.; Schmidt, B.; Wagner, R.; Gessner, A.; Burkhard, R.; Offner, R. 2020, PLoS ONE 15(12): e0243967.

A highly specific and sensitive serological assay detects SARS‑CoV‑2 antibody levels in COVID‑19 patients that correlate with neutralization
Peterhoff, D.; Glück, V.; Vogel, M.; Schuster, P.; Schütz, A.; Neubert, P.; Albert, V.; Frisch, S.; Kiessling, M.; Pervan, P.; Werner, M.; Ritter, N.; Babl, L,; Deichner, M,; Hanses, F.; Lubnow, Müller, T.; Lunz, D.; Hitzenbichler, F.; Audebert, F.; Hähnel, V.; Offner, R.; Müller, M.; Schmid, S.; Burkhardt, R.; Glück, T.; Koller, M.; Niller, H.H.; Graf, B.; Salzberger, B.; Wenzel, J.; Jantsch, J.; Gessner, A.;  Schmidt, B.; Wagner, R.  2020 Infection

Epidemiology of SARS‑CoV‑2
Salzberger, F. Buder, · B. T. Lampl, · B. Ehrenstein,· F. Hitzenbichler, T. Holzmann, · B.  Schmidt,  F. Hanses, 2020,Infection

Epidemiologie von SARSCoV-2/COVID 19
Salzberger, B.; Buder, F.; Lampl, B.; Ehrenstein,B.; Hitzenbichler, F.; Holzmann, T.; Schmidt, B.;  Hanses, F. 2020, Gastroenterologe

SARS-CoV-2/COVID-19-epidemiology and prevention.
Salzberger B, Buder F, Lampl B, Ehrenstein B, Hitzenbichler F, Holzmann T, Schmidt B, Hanses F. Nephrologe. 2020 Dec 15:1-7. doi: 10.1007/s11560-020-00472-0.

Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson’s disease: balancing immunosuppression
Lubnow, L.; Schmidt, B.; Fleck, M.; Salzberger, B.; Müller, T.; Peschel, P.; Schneckenpointner, R.; Lange, T.; Hitzenbichler F.; Kieninger, M.; Lunz, D.; Graf, B.; Brochhausen, C.; Weber F.; Lüke, F.; Schuster, P.; Hiergeist, A.; Heudobler, D. 2020, IJID

Successful containment of Covid-19 outbreak in a large maternity and perinatal center while continuing clinical service.
Kabesch M, Roth S, Brandstetter S, Häusler S, Juraschko E, Weigl M, Wellmann S, Lang T, Schmidt B, Salzberger B, Ambrosch A. Pediatr Allergy Immunol. 2020 Jul;31(5):560-564. doi: 10.1111/pai.13265.

Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples.
Eis-Hübinger AM, Hönemann M, Wenzel JJ, Berger A, Widera M, Schmidt B, Aldabbagh S, Marx B, Streeck H, Ciesek S, Liebert UG, Huzly D, Hengel H, Panning M. J Clin Virol. 2020 Jun;127:104381. doi: 10.1016/j.jcv.2020.104381.