Arbeitsgruppe Prof. Dr. Jürgen Wenzel
Telefon | +49 (0) 941 - 944 6411 | ||||
Telefax | +49 (0) 941 - 944 6402 | ||||
juergen.wenzel@ukr.de | |||||
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Publikationen
UNSERE PROJEKTE
Alle aktuellen Projekte unserer Arbeitsgruppe auf einen Blick:
Hepatitis E auch in Deutschland relevant
Die Hepatitis E kommt auch in Deutschland häufig vor. Bei der labordiagnostischen Abklärung einer akuten Hepatitis sollte deshalb auch an … Weiterlesen Hepatitis E auch in Deutschland relevant
Impfschutz unserer Kinder und Jugendlichen nach Impfung gegen das Hepatitis B Virus
Seit knapp 20 Jahren impfen wir alle unsere Säuglinge gegen Hepatitis B Virus (HBV). Nach der Grundimmunisierung ist allerdings keine … Weiterlesen Impfschutz unserer Kinder und Jugendlichen nach Impfung gegen das Hepatitis B Virus
MITARBEITER
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UNSERE NEWS
Alle aktuellen News unserer Arbeitsgruppe auf einen Blick:
Vollständige und aktuelle Liste:
https://orcid.org/0000-0001-8422-6581
https://orcid.org/0000-0001-8422-6581
2019
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- Schemmerer M, Johne R, Erl M, Jilg W, Wenzel JJ: Isolation of Subtype 3c, 3e and 3f-Like Hepatitis E Virus Strains Stably Replicating to High Viral Loads in an Optimized Cell Culture System. Viruses. 2019;11(6). pii: E483. https://doi.org/10.3390/v11060483
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- Friebus-Kardash J, Eisenberger U, Ackermann J, Kribben A, Witzke O, Wenzel J, Rohn H, Fiedler M: Prevalence of Active Hepatitis E Virus Infection and Efficacy of Ribavirin Treatment in Renal Allograft Recipients. Transpl Infect Dis 2019, :e13088. [im Druck] doi: 10.1111/tid.13088
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- Marosevic D, Belting A, Schönberger K, Carl A, Wenzel JJ, Brey R: Hepatitis A Outbreak in the General Population due to a MSM-Associated HAV Genotype Linked to a Food Handler, November 2017–February 2018, Germany. Food Environ Virol 2019. [im Druck] doi: 10.1007/s12560-019-09375-3
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2018
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- Darstein F, Häuser F, Straub BK, Wenzel JJ, Conradi R, Mittler J, Lang H, Galle PR, Zimmermann T: Hepatitis E virus genotype 3 is a common finding in liver-transplanted patients undergoing liver biopsy for elevated liver enzymes with a low De Ritis ratio and suspected acute rejection: A real-world cohort. Clin Transplant 2018, 32(11):e13411. doi: 10.1111/ctr.13411
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- Ndumbi P, Freidl GS, Williams CJ, Mardh O, Varela C, Avellon A, Friesema I, Vennema H, Beebeejaun K, Ngui SL, Edelstein M, Smith-Palmer A, Murphy N, Dean J, Faber M, Wenzel J, Kontio M, Müller L, Midgley SE, Sundqvist L, Ederth JL, Roque-Afonso AM, Couturier E, Klamer S, Rebolledo J, Suin V, Aberle SW, Schmid D, De Sousa R, Augusto GF, Alfonsi V, Del Manso M, Ciccaglione AR, Mellou K, Hadjichristodoulou C, Donachie A, Borg ML, Socan M, Poljak M, Severi E, Team MOTEHAOI: Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017. Euro Surveill 2018, 23(33). doi: 10.2807/1560-7917.ES.2018.23.33.1700641
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- Mahrt H, Schemmerer M, Behrens G, Leitzmann M, Jilg W, Wenzel JJ:
Continuous decline of hepatitis E virus seroprevalence in southern Germany despite increasing notifications, 2003–2015. Emerg Microbes Infect 2018, 7:133. doi: 10.1038/s41426-018-0136-8
- Mahrt H, Schemmerer M, Behrens G, Leitzmann M, Jilg W, Wenzel JJ:
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- Gassowski M, Michaelis K, Wenzel JJ, Faber M, Figoni J, Mouna L, Friesema IH, Vennema H, Avellon A, Varela C, Sundqvist L, Lundberg Ederth J, Plunkett J, Balogun K, Ngui SL, Midgley SE, Gillesberg Lassen S, Müller L: Two concurrent outbreaks of hepatitis A highlight the risk of infection for non-immune travellers to Morocco, January to June 2018. Euro Surveill 2018, 23(27). doi: 10.2807/1560-7917.ES.2018.23.27.1800329
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- Fritz M, Berger B, Schemmerer M, Endres D, Wenzel JJ, Stich O, Panning M: Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection. J Infect Dis 2018, 217(12):1897–1901. doi: 10.1093/infdis/jiy128
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- Cordts SE, Schneble L, Schnitzler P, Wenzel JJ, Vinke T, Rieger S, Fichtner A, Tönshoff B, Höcker B: Prevalence, morbidity, and therapy of hepatitis E virus infection in pediatric renal allograft recipients. Pediatr Nephrol 2018, 33(7):1215–1225. doi: 10.1007/s00467-018-3905-7
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- Faber M, Willrich N, Schemmerer M, Rauh C, Kuhnert R, Stark K, Wenzel JJ: Hepatitis E virus seroprevalence, seroincidence and seroreversion in the German adult population. J Viral Hepat 2018, 25(6):752–758. doi: 10.1111/jvh.12868
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- Weigand K, Weigand K, Schemmerer M, Müller M, Wenzel JJ: Hepatitis E Seroprevalence and Genotyping in a Cohort of Wild Boars in Southern Germany and Eastern Alsace. Food Environ Virol 2018, 10(2):167–175. doi: 10.1007/s12560-017-9329-x
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2017
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- Roth NJ, Schäfer W, Alexander R, Elliott K, Elliott-Browne W, Knowles J, Wenzel JJ, Simon TL: Low hepatitis E virus RNA prevalence in a large-scale survey of United States source plasma donors. Transfusion 2017, 57(12):2958–2964. doi: 10.1111/trf.14285
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- Michaelis K, Wenzel JJ, Stark K, Faber M: Hepatitis A virus infections and outbreaks in asylum seekers arriving to Germany, September 2015 to March 2016. Emerg Microbes Infect 2017, 6(4):e26. doi: 10.1038/emi.2017.11
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- Heyd R, Eis-Hübinger AM, Berger A, Bierbaum S, Pietzonka S, Wenzel JJ, Huzly D, Keppler OT, Panning M: Retrospective analysis of clinical and virological parameters of influenza cases at four university hospitals in Germany, 2015. Infection 2017, 45(3):349–354. doi: 10.1007/s15010-017-1008-1
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- Werber D, Michaelis K, Hausner M, Sissolak D, Wenzel J, Bitzegeio J, Belting A, Sagebiel D, Faber M: Ongoing outbreaks of hepatitis A among men who have sex with men (MSM), Berlin, November 2016 to January 2017 - linked to other German cities and European countries. Euro Surveill 2017, 22(5). doi: 10.2807/1560-7917.ES.2017.22.5.30457
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- Schemmerer M, Rauh C, Jilg W, Wenzel JJ: Time course of hepatitis E-specific antibodies in adults. J Viral Hepat 2017, 24:75–79. doi: 10.1111/jvh.12621
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2016
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- Schemmerer M, Apelt S, Trojnar E, Ulrich RG, Wenzel JJ, Johne R: Enhanced Replication of Hepatitis E Virus Strain 47832c in an A549-Derived Subclonal Cell Line. Viruses 2016, 8(10). doi: 10.3390/v8100267
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- Brunskole Hummel I, Zitzmann A, Erl M, Wenzel JJ, Jilg W: Characteristics of immune memory 10–15 years after primary hepatitis B vaccination. Vaccine 2016, 34(5):636–42. doi: 10.1016/j.vaccine.2015.12.033
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- Brunskole Hummel I, Huber B, Wenzel JJ, Jilg W: Markers of Protection in Children and Adolescents Six to Fourteen Years After Primary Hepatitis B Vaccination in Real Life: A Pilot Study. Pediatr Infect Dis J 2016, 35(3):286–91. doi: 10.1097/INF.0000000000000994
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2015
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- Mankertz A, Beutel U, Schmidt FJ, Borgmann S, Wenzel JJ, Ziegler P, Weißbrich B, Santibanez S: Laboratory-based investigation of suspected mumps cases submitted to the German National Reference Centre for Measles, Mumps, and Rubella, 2008 to 2013. Int J Med Microbiol 2015, 305(7):619–26. doi: 10.1016/j.ijmm.2015.08.011
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- Guzman-Herrador BR, Panning M, Stene-Johansen K, Borgen K, Einöder-Moreno M, Huzly D, Jensvoll L, Lange H, Maassen S, Myking S, Myrmel M, Neumann-Haefelin C, Nygard K, Wenzel JJ, Oye AK, Vold L: Importance of molecular typing in confirmation of the source of a national hepatitis A virus outbreak in Norway and the detection of a related cluster in Germany. Arch Virol 2015, 160(11):2823–6. doi: 10.1007/s00705-015-2531-y
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- Severi E, Verhoef L, Thornton L, Guzman-Herrador BR, Faber M, Sundqvist L, Rimhanen-Finne R, Roque-Afonso AM, Ngui SL, Allerberger F, Baumann-Popczyk A, Muller L, Parmakova K, Alfonsi V, Tavoschi L, Vennema H, Fitzgerald M, Myrmel M, Gertler M, Ederth J, Kontio M, Vanbockstael C, Mandal S, Sadkowska-Todys M, Tosti ME, Schimmer B, O Gorman J, Stene-Johansen K, Wenzel JJ, Jones G, Balogun K, Ciccaglione AR, O Connor L, Vold L, Takkinen J, Rizzo C: Large and prolonged food-borne multistate hepatitis A outbreak in Europe associated with consumption of frozen berries, 2013 to 2014. Euro Surveill 2015, 20(29). doi: 10.2807/1560-7917.ES2015.20.29.21192
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- Wenzel JJ, Jilg W: Reply: To PMID 24912687. Hepatology 2015, 62(2):654. doi: 10.1002/hep.27613
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2014
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- Harries M, Monazahian M, Wenzel J, Jilg W, Weber M, Ehlers J, Dreesman J, Mertens E. Foodborne hepatitis A outbreak associated with bakery products in northern Germany, 2012. Euro Surveill. 2014 Dec 18;19(50).
doi: 10.2807/1560-7917.ES2014.19.50.20992
- Harries M, Monazahian M, Wenzel J, Jilg W, Weber M, Ehlers J, Dreesman J, Mertens E. Foodborne hepatitis A outbreak associated with bakery products in northern Germany, 2012. Euro Surveill. 2014 Dec 18;19(50).
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- Wenzel JJ, Allerberger F. Hepatitis A as a foodborne infection. Lancet Infect Dis. 2014 doi:10.1016/S1473-3099(14)70897-7
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- Wenzel JJ, Schemmerer M, Oberkofler H, Kerschner H, Sinha P, Koidl C, Allerberger F. Hepatitis A Outbreak in Europe: Imported Frozen Berry Mix Suspected to be the Source of At least One Infection in Austria in 2013. Food Environ Virol. 2014 Sep 3. doi: 10.1007/s12560-014-9165-1
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- Tabatabai J & Wenzel JJ, et al.. First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany. J Clin Virol (2014). doi: 10.1016/j.jcv.2014.06.008
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- Wenzel JJ, Sichler M, Schemmerer M, Behrens G, Leitzmann MF, Jilg W. Decline in hepatitis E virus antibody prevalence in Southeastern Germany, 1996-2011. Hepatology. 2014 Jun 9. doi: 10.1002/hep.27244
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- Huzly D, Umhau M, Bettinger D, Cathomen T, Emmerich F, Hasselblatt P, Hengel H, Herzog R, Kappert O, Maassen S, Schorb E, Schulz-Huotari C, Thimme R, Unmussig R, Wenzel J, Panning M.: Transfusion-transmitted hepatitis E in Germany, 2013.
Euro Surveill. 2014 May 29;19(21). pii: 20812. PubMed PMID: 24906377
- Huzly D, Umhau M, Bettinger D, Cathomen T, Emmerich F, Hasselblatt P, Hengel H, Herzog R, Kappert O, Maassen S, Schorb E, Schulz-Huotari C, Thimme R, Unmussig R, Wenzel J, Panning M.: Transfusion-transmitted hepatitis E in Germany, 2013.
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- Scharn N, Ganzenmueller T, Wenzel JJ, Dengler R, Heim A, Wegner F: Guillain-Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c. Infection 2014, 42:171–3. doi: 10.1007/s15010-013-0448-5
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2013
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- Wenzel JJ, Preiss J, Schemmerer M, Huber B, Jilg W: Test Performance Characteristics of Anti-HEV IgG Assays Strongly Influence Hepatitis E Seroprevalence Estimates. J Infect Dis 2013, 207(3):497–500. doi: 10.1093/infdis/jis688
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- Pischke S, Hardtke S, Bode U, Birkner S, Chatzikyrkou C, Kauffmann W, Bara CL, Gottlieb J, Wenzel J, Manns MP, Wedemeyer H: Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience. Liver Int 2013, 33(5):722–726. doi: 10.1111/liv.12114
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- Launay O, Duval X, Fitoussi S, Jilg W, Kerdpanich A, Montellano M, Schwarz TF, Watanveerade V, Wenzel JJ, Zalcman G, Bambure V, Li P, Caplanusi A, Madan A, Gillard P, Vaughn DW: Extended antigen sparing potential of AS03-adjuvanted pandemic H1N1 vaccines in children, and immunological equivalence of two formulations of AS03-adjuvanted H1N1 vaccines: results from two randomised trials. BMC Infect Dis 2013, 13:435. doi: 10.1186/1471-2334-13-435
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- Baylis SA, Blümel J, Mizusawa S, Matsubayashi K, Sakata H, Okada Y, Nübling CM, Hanschmann KMO, HEV Collaborative Study Group: World health organization international standard to harmonize assays for detection of hepatitis e virus RNA. Emerg Infect Dis 2013, 19(5):729–735. doi: 10.3201/eid1905.121845
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- Bauernfeind S, Bruennler T, Ehrenstein B, Langgartner J, Wenzel JJ, Werner S, Lubnow M, Mueller T, Floerchinger B, Salzberger B: Pandemic and post-pandemic influenza A (H1N1) seasons in a tertiary care university hospital-high rate of complications compared to previous influenza seasons. Infection 2013, 41:145–150. doi: 10.1007/s15010-012-0310-1
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2012
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- Krumbholz A, Mohn U, Lange J, Motz M, Wenzel JJ, Jilg W, Walther M, Straube E, Wutzler P, Zell R: Prevalence of hepatitis E virus-specific antibodies in humans with occupational exposure to pigs. Med Microbiol Immunol 2012, 201(2):239–244. doi: 10.1007/s00430-011-0210-5
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- Faber MS, Wenzel JJ, Jilg W, Thamm M, Höhle M, Stark K: Hepatitis E Virus Seroprevalence among Adults, Germany. Emerg Infect Dis 2012, 18(10):1654–1657. doi: 10.3201/eid1810.111756
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- Hoerning A, Hegen B, Wingen AM, Cetiner M, Lainka E, Kathemann S, Fiedler M, Timm J, Wenzel JJ, Hoyer PF, Gerner P: Prevalence of hepatitis E virus infection in pediatric solid organ transplant recipients – A single-center experience. Pediatr Transplant 2012, 16(7):742–747. doi: 10.1111/j.1399-3046.2012.01740.x
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- Gauss A, Wenzel JJ, Flechtenmacher C, Navid MH, Eisenbach C, Jilg W, Stremmel W, Schnitzler P: Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report. J Med Case Rep 2012, 6:334. doi: 10.1186/1752-1947-6-334
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- Dremsek P, Wenzel JJ, Johne R, Ziller M, Hofmann J, Groschup MH, Werdermann S, Mohn U, Dorn S, Motz M, Mertens M, Jilg W, Ulrich RG: Seroprevalence study in forestry workers from eastern Germany using novel genotype 3- and rat hepatitis E virus-specific immunoglobulin G ELISAs. Med Microbiol Immunol 2012, 201(2):189–200. doi: 10.1007/s00430-011-0221-2
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- Baylis SA, Ma L, Padley DJ, Heath AB, Yu MW, Collaborative Study Group: Collaborative study to establish a World Health Organization International genotype panel for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays. Vox Sang 2012, 102(3):204–211. doi: 10.1111/j.1423-0410.2011.01541.x
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2011
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- Wenzel JJ, Preiß J, Schemmerer M, Huber B, Plentz A, Jilg W: Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J Clin Virol 2011, 52:50–54. doi: 10.1016/j.jcv.2011.06.006
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- Veitt R, Reichardt M, Wenzel J, Jilg W: Autochthonous Hepatitis E-Virus Infection as Cause of Acute Hepatitis in Germany – a Case Report. Z Gastroenterol 2011, 49:42–46. doi: 10.1055/s-0029-1245767
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- Modrow S, Wenzel JJ, Schimanski S, Schwarzbeck J, Rothe U, Oldenburg J, Jilg W, Eis-Hübinger AM: Prevalence of nucleic acid sequences specific for human parvoviruses, hepatitis A and hepatitis E viruses in coagulation factor concentrates. Vox Sang 2011, 100(4):351–358. doi: 10.1111/j.1423-0410.2010.01445.x
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- Bredl S, Plentz A, Wenzel JJ, Pfister H, Möst J, Modrow S: False-negative serology in patients with acute parvovirus B19 infection. J Clin Virol 2011, 51(2):115–120. doi: 10.1016/j.jcv.2011.03.012
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- Baylis SA, Hanschmann KM, Blümel J, Nübling CM, on behalf of the HEV Collaborative Study Group: Standardization of Hepatitis E Virus (HEV) Nucleic Acid Amplification Technique-Based Assays: an Initial Study To Evaluate a Panel of HEV Strains and Investigate Laboratory Performance. J Clin Microbiol 2011, 49(4):1234–1239. doi: 10.1128/JCM.02578-10
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2010
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- Wenzel JJ, Jilg W: Loss of antibodies, but not of protection. Lancet Infect Dis 2010, 10(11):738–739. doi: 10.1016/S1473-3099(10)70217-6
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- Wenzel JJ, Panning M, Kaul KL, Mangold KA, Revell PA, Luna RA, Zepeda H, Perea L, Vazquez-Perez JA, Young S, Rodic-Polic B, Eickmann M, Drosten C, Jilg W, Reischl U: Analytical Performance Determination and Clinical Validation of the Novel Roche RealTime Ready Influenza A/H1N1 Detection Set. J Clin Microbiol 2010, 48(9):3088–3094. doi: 10.1128/JCM.00785-10
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- Otto W, Mankertz A, Santibanez S, Saygili H, Wenzel J, Jilg W, Wieland W, Borgmann S: Ongoing outbreak of mumps affecting adolescents and young adults in Bavaria, Germany, August to October 2010. Euro Surveill 2010, 15(50). doi: 10.2807/ese.15.50.19748-en
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- Brost S, Wenzel JJ, Ganten TM, Filser M, Flechtenmacher C, Boehm S, Astani A, Jilg W, Zeier M, Schnitzler P: Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany. J Clin Virol 2010, 47:89–92. doi: 10.1016/j.jcv.2009.10.011
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2009
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- Wenzel JJ, Walch H, Bollwein M, Niller HH, Ankenbauer W, Mauritz R, Höltke HJ, Zepeda HM, Wolf H, Jilg W, Reischl U: Library of Prefabricated Locked Nucleic Acid Hydrolysis Probes Facilitates Rapid Development of Reverse-Transcription Quantitative Real-Time PCR Assays for Detection of Novel Influenza A/H1N1/09 Virus.Clin Chem 2009, 55(12):2218–2222. doi: 10.1373/clinchem.2009.136192
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- Wenzel JJ, Hentschel J, Silvis W, Permanetter W, Mattes J, Kochanowski B, Herterich R, Jilg W, Linde HJ: Rapidly fatal necrotizing pneumonia in a 12-year-old boy caused by co-infection with parainfluenza virus type 1 and Panton-Valentine leukocidin (PVL)-positive methicillin-sensitive Staphylococcus aureus. Infection 2009, 37:75–77. doi: 10.1007/s15010-008-8214-9
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- Panning M, Eickmann M, Landt O, Monazahian M, Olschläger S, Baumgarte S, Reischl U, Wenzel JJ, Niller HH, Günther S, Hollmann B, Huzly D, Drexler JF, Helmer A, Becker S, Matz B, Eis-Hübinger A, Drosten C: Detection of influenza A(H1N1)v virus by real-time RT-PCR. Euro Surveill 2009, 14(36). doi: 10.2807/ese.14.36.19329-en
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- Melzl H, Wenzel JJ, Feierabend K, Kreuzpaintner B, Kreuzpaintner E, Rohrhofer A, Schreder-Meindl S, Wollner H, Salzberger B, Reischl U, Jilg W, Wolf H, Niller HH: First sequence-confirmed case of infection with the new influenza A(H1N1) strain in Germany. Euro Surveill 2009, 14(18). doi: 10.2807/ese.14.18.19203-en
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- Lindner J, Noutsias M, Lassner D, Wenzel J, Schultheiss HP, Kuehl U, Modrow S: Adaptive immune responses against parvovirus B19 in patients with myocardial disease. J Clin Virol 2009, 44:27–32. doi: 10.1016/j.jcv.2008.09.007
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- Kuethe F, Lindner J, Matschke K, Wenzel JJ, Norja P, Ploetze K, Schaal S, Kamvissi V, Bornstein SR, Schwanebeck U, Modrow S: Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis. Clin Infect Dis 2009, 49(11):1660–1666. doi: 10.1086/648074
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- Enders M, Lindner J, Wenzel JJ, Baisch C, Schalasta G, Enders G, Modrow S: No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions. J Clin Virol 2009, 45(4):300–303. doi: 10.1016/j.jcv.2009.04.005