Arbeitsgruppe PD Dr. Nahed El-Najjar
Prof. Dr. Nahed El-Najjar ist seit dem 1. Oktober 2023 Associate Professor am Department of Pharmacology and Toxicology der American University of Beirut
P.O. Box: 11-0236, Beirut, Lebanon
| ne09@aub.edu.lb | |||||
UNSERE PROJEKTE
Alle aktuellen Projekte unserer Arbeitsgruppe auf einen Blick:
Interactions between AB and AC
Drug-drug interactions account for 4% of death of cancer patients. Antibiotics (AB) and antineoplastic agents (AC) are characterized by their … Weiterlesen Interactions between AB and AC
MITARBEITER
Hier finden Sie den richtigen Ansprechpartner:
2022
• Pfab C, Abragyan A, Danzer B, Mourtada F; Ali W; Gessner A, EL-Najjar N.
Ceftazidimeand Cefepime antagonize 5-fluorouracil’s effect in colon cancer cells.
BMC Cancer 2022 Jan 31;22(1):125.
• Busse D, Simon P, Petroff D, El-Najjar N, Schmitt L, Bindellini D, Dietrich A, Zeitlinger A, Huisinga W, Michelet R, Wrigge H, Kloft C.
Fosfomycin high dosage results in adequate plasma and target-site exposure in morbidly obese and nonobese non-hyperfiltration patients.
Antimicrobial Agents and Chemotherapy. 2022 Jun 21;66(6):e0230221
• Schneider F, Gessner A, El-Najjar N.
Efficacy of Vancomycin and Meropenem in central nervous system’ infections in children and adults:current update.
Antibiotics 2022 Jan 28;11(2):173
2021
• Busse D, Borghardt JM , Petroff D, Pevzner A , Dorn C , El-Najjar N , Huisinga W , Wrigge H, Simon P, Kloft C
Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and non-obese patients, 2021,
British Journal of Clinical Pharmacology
• Pfab C; Schnobrich L; Eldnasoury S; Gessner A; El-Najjar N.
Repurposing of Antimicrobial Agents for Cancer Therapy: What Do We Know?.
Cancers 2021, 13, 3193. https://doi.org/10.3390/ cancers13133193
2020
• Stolte M, Ali W, Jänis J, Gessner A, El-Najjar N.
Paclitaxel, Imatinib and 5-Fluorouracil Increase the Unbound Fraction of Flucloxacillin In Vitro.
Antibiotics (Basel). 2020 Jun 8;9(6):309. doi: 10.3390/antibiotics9060309.
2019
• Dorn C, Petroff D, Neumann N, Kratzer A, El-Najjar N, Dietrich A, Kloft C, Zeitlinger M, Kees M, Kees F, Wrigge H, Simon P.
Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients – a controlled clinical trial.
Journal of Antimicrobial Chemotherapy (doi:10.1093/jac/dkz203)
2018
• Hösl J, Gessner A, El-Najjar N.
Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma.
Journal of Pharmaceutical and Biomedical Analysis. 2018 Aug 5;157:92-99.
• Chotikatum S, Naim HY, El-Najjar N.
Inflammation induced ER stress affects absorptive intestinal epithelial cells function and integrity.
International Immunopharmacology. 2018 Jan 8;55:336-344.
2017
• El-Najjar N, Hösl J, Holzmann T, Jantsch J, Gessner A.
UPLC-MS/MS Method for Therapeutic Drug Monitoring of Ten Antibiotics used in Intensive Care Units.
Drug Test Anal. 2017 July 28.
• El-Najjar N, Jantsch J, Gessner A.
A rapid liquid chromatography-tandem mass spectrometry for the quantification of Fosfomycin in plasma, urine, and aqueous fluids.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:57-64.
• El-Najjar N, Kullkarni R, Nader N, Machaca K.
Effects of hyperglycemia on vascular smooth muscle Calcium signaling.
Biomed Res Int. 2017;2017:3691349.
• El-Najjar N, Jantsch J, Gessner A.
The use of liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of antibiotics in cancer patients.
Clin Chem Lab Med. 2017 Jan 11.
2015
• El-Najjar N, Orsó E, Wallner S, Liebisch G, Schmitz G.
Alterations of plasma sphingosylphosphorylcholine levels in metabolic syndrome but not in patients at risk for diabesity.
PLoS One. 2015 Oct 14;10(10):e0140683
2013
• Wirries A, Schubert AK, Zimmermann R, Jabari S, Ruchholtz S, El-Najjar N.
Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway.
International Immunopharmacology. 2013; 15: 381-386.
• El-Najjar N, Gali-Muhtasib H, Vuorela P, Urtti A, Vuorela H.
Naphtoquinones and Anthraquinones: chemical, analytical, and biological overview.
Handbook of Chemical and Biological Plant Analytical Methods 2013.
2012
• Rossi M, Bolz C, Revez J, Javed S, El-Najjar N, Hyytiaeinen H, Vuorela P, Gerhard M, Haenninen ML.
Evidence for Conserved Function of glutamyltranspeptidase in Helicobacter Genus.
PLoS One. 2012; 7(2):e30543.
2011
• El-Najjar N, Gali-Muhtasib H, Ketola R, Vuorela P, Urtti A, Vuorela H.
The chemical and biological activities of quinones: overview and implications in analytical detection.
Phytochemistry Review 2011; 10: 353-70.
• El-Najjar N, Ketotal RA, Nissilä T, Mauriala T, Antopolsky M, Gali-Muhtasib H, Urtti A, Vuorela H.
Impact of protein binding on Thymoquinone’s analytical detectability and anticancer activity.
Journal of Chemical Biology. 2011; 4: 97-107.
• Kliebe F, Wack C, Erber P, Vackiner E, El-Najjar N, Ruchholtz S.
Knochendefektheilung am Osteoporosemodell der Ratte unter Lokalapplikation von Osteoprotegerin mittels einer resorbierbaren Trägermatrix. (Translation: bone defect healing in the rat model of osteoporosis under local administration of osteoprotegerin by means of a resorbable carrier matrix.).
Biomaterialien. Band 12, Heft 1-4, Seiten 57–59, ISSN (Online) 2191-4672, ISSN (Print) 1616-0177, DOI: 10.1515/biomat.2011.004, November 2011
2010
• El-Najjar N, Chatila M, Mokadem H, Vuorela H, Ocker M, Gandesiri M, Schneider-Stock R, Gali-Muhtasib H. Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signalling. Apoptosis. 2010; 15(2): 183-195.
2008
• Gali-Muhtasib H, Krueger S, El-Hajj Z, Kuester D, El-Najjar N, Peters B, Jurjus A, Roessner A, Schneider-Stock R. Thymoquinone inhibits invasion of mouse colon tumor cells and prevents 1,2-dimethylhydrazine-induced mouse colon carcinogenesis. Journal of Cellular and Molecular Medicine. 2008; 12(1): 330-342.
• El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba N, Gali-Muhtasib H. Antitumor effects of Salograviolide A isolated from Centaurea ainetensis in Colon Cancer. Oncology Report. 2008; 19 (4): 897-904.
2007
• El-Najjar N, Saliba N, Talhouk S and Gali-Muhtasib H. Induction of apoptosis and protection against 1,2-dimethylhydrazine induced colon cancer by the extract of Onopordum cynarocephalum. Oncology Report. 2007 June; 17 (6): 1517-1523.
2006
• Gali-Muhtasib H, El-Najjar N and Schneider-Stock R. The Medicinal Potential of Black seed (Nigella sativa) and its Components. Advances in Phytomedicine, Vol 2. Lead Molecules from Natural Products: Discovery and New Trends, Editors: M.T. Khan and Arjumand Ather, Elsevier Publishers, 2006.