MIKROBIOM

Publikationen:

Weber D, Weber M, Meedt E, Ghimire S, Wolff D, Edinger M, Poeck H, Hiergeist A, Gessner A, Ayuk F, Roesler W, Wölfl M, Kraus S, Zeiser R, Bertrand H, Bader P, Ullrich E, Eder M, Gleich S, Young R, Herr W, Levine JE, Ferrara JLM, Holler E
Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use.
Blood Adv. 2023 Apr 11;7(7):1326-1335. doi: 10.1182/bloodadvances.2022008480.PMID: 36350750 Free PMC article.

Matos C, Mamilos A, Shah PN, Meedt E, Weber D, Ghimire S, Hiergeist A, Gessner A, Dickinson A, Dressel R, Walter L, Stark K, Heid IM, Poeck H, Edinger M, Wolff D, Herr W, Holler E, Kreutz M, Ghimire S.
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation.
Front Immunol. 2022 Oct 20;13:1028850. doi: 10.3389/fimmu.2022.1028850. eCollection 2022.PMID: 36341397 Free PMC article.

Nausch B, Bittner CB, Höller M, Abramov-Sommariva D, Hiergeist A, Gessner A.
Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health.
Antibiotics (Basel). 2022 Sep 29;11(10):1331. doi: 10.3390/antibiotics11101331.PMID: 36289988 Free PMC article. Review.

Mao X, Hiergeist A, Auer DL, Scholz KJ, Muehler D, Hiller KA, Maisch T, Buchalla W, Hellwig E, Gessner A, Al-Ahmad A, Cieplik F.
Ecological Effects of Daily Antiseptic Treatment on Microbial Composition of Saliva-Grown Microcosm Biofilms and Selection of Resistant Phenotypes.
Front Microbiol. 2022 Jun 30;13:934525. doi: 10.3389/fmicb.2022.934525. eCollection 2022.PMID: 35847089 Free PMC article.

Stumptner C, Stadlbauer V, O'Neil D, Gessner A, Hiergeist A, Zatloukal K, Abuja PM.
The Pre-Analytical CEN/TS Standard for Microbiome Diagnostics-How Can Research and Development Benefit?
Nutrients. 2022 May 9;14(9):1976. doi: 10.3390/nu14091976.PMID: 35565946 Free PMC article.

de Castilhos J, Zamir E, Hippchen T, Rohrbach R, Schmidt S, Hengler S, Schumacher H, Neubauer M, Kunz S, Müller-Esch T, Hiergeist A, Gessner A, Khalid D, Gaiser R, Cullin N, Papagiannarou SM, Beuthien-Baumann B, Krämer A, Bartenschlager R, Jäger D, Müller M, Herth F, Duerschmied D, Schneider J, Schmid RM, Eberhardt JF, Khodamoradi Y, Vehreschild MJGT, Teufel A, Ebert MP, Hau P, Salzberger B, Schnitzler P, Poeck H, Elinav E, Merle U, Stein-Thoeringer CK.
Correction to: Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients.
Clin Infect Dis. 2022 Aug 24;75(1):185. doi: 10.1093/cid/ciac254.PMID: 35536665 Free PMC article. No abstract available.

Weber D, Meedt E, Poeck H, Thiele-Orberg E, Hiergeist A, Gessner A, Holler E.
Fecal Microbiota Transfer in Acute Graft-versus-Host Disease following Allogeneic Stem Cell Transplantation.
Visc Med. 2024 Mar 26:1-6. doi: 10.1159/000538303. Online ahead of print.PMID: 39047173 Free PMC article. Review.

Schreiber L, Ghimire S, Hiergeist A, Renner K, Althammer M, Babl N, Peuker A, Schoenhammer G, Hippe K, Gessner A, Albrecht C, Pielmeier F, Büttner-Herold M, Bruns H, Hoffmann P, Herr W, Holler E, Peter K, Kreutz M, Matos C.
Strain specific differences in vitamin D3 response: impact on gut homeostasis.
Front Immunol. 2024 Mar 1;15:1347835. doi: 10.3389/fimmu.2024.1347835. eCollection 2024.PMID: 38495883 Free PMC article.

Bülow S, Ederer KU, Holzinger JM, Zeller L, Werner M, Toelge M, Pfab C, Hirsch S, Göpferich F, Hiergeist A, Berberich-Siebelt F, Gessner A.
Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response.
Cell Rep. 2024 Mar 26;43(3):113929. doi: 10.1016/j.celrep.2024.113929. Epub 2024 Mar 7.PMID: 38457343

Thiele Orberg E, Meedt E, Hiergeist A, Xue J, Heinrich P, Ru J, Ghimire S, Miltiadous O, Lindner S, Tiefgraber M, Göldel S, Eismann T, Schwarz A, Göttert S, Jarosch S, Steiger K, Schulz C, Gigl M, Fischer JC, Janssen KP, Quante M, Heidegger S, Herhaus P, Verbeek M, Ruland J, van den Brink MRM, Weber D, Edinger M, Wolff D, Busch DH, Kleigrewe K, Herr W, Bassermann F, Gessner A, Deng L, Holler E, Poeck H.
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation.
Nat Cancer. 2024 Jan;5(1):187-208. doi: 10.1038/s43018-023-00669-x. Epub 2024 Jan 3.PMID: 38172339

Manook A, Baghai TC, Riebel M, Nothdurfter C, Schwarzbach JV, Gessner A, Rupprecht R, Hiergeist A.
Short-term effects of etifoxine on human gut microbiome in healthy men.
Front Neurosci. 2023 Nov 14;17:1188847. doi: 10.3389/fnins.2023.1188847. eCollection 2023.PMID: 38075272 Free PMC article.

Jarosch S, Köhlen J, Ghimire S, Orberg ET, Hammel M, Gaag D, Evert M, Janssen KP, Hiergeist A, Gessner A, Weber D, Meedt E, Poeck H, D'Ippolito E, Holler E, Busch DH.
Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD.
Cell Rep Med. 2023 Jul 18;4(7):101125. doi: 10.1016/j.xcrm.2023.101125.PMID: 37467715 Free PMC article.

Weber D, Hiergeist A, Weber M, Ghimire S, Salzberger B, Wolff D, Poeck H, Gessner A, Edinger M, Herr W, Meedt E, Holler E.
Restrictive Versus Permissive Use of Broad-spectrum Antibiotics in Patients Receiving Allogeneic Stem Cell Transplantation and With Early Fever Due to Cytokine Release Syndrome: Evidence for Beneficial Microbiota Protection Without Increase in Infectious Complications.
Clin Infect Dis. 2023 Nov 17;77(10):1432-1439. doi: 10.1093/cid/ciad389.PMID: 37386935

Hoelz H, Heetmeyer J, Tsakmaklis A, Hiergeist A, Siebert K, De Zen F, Häcker D, Metwaly A, Neuhaus K, Gessner A, Vehreschild MJGT, Haller D, Schwerd T.
Is Autologous Fecal Microbiota Transfer after Exclusive Enteral Nutrition in Pediatric Crohn's Disease Patients Rational and Feasible? Data from a Feasibility Test.
Nutrients. 2023 Apr 2;15(7):1742. doi: 10.3390/nu15071742.PMID: 37049583 Free PMC article.

Hiergeist A, Ruelle J, Emler S, Gessner A.
Reliability of species detection in 16S microbiome analysis: Comparison of five widely used pipelines and recommendations for a more standardized approach.
PLoS One. 2023 Feb 16;18(2):e0280870. doi: 10.1371/journal.pone.0280870. eCollection 2023.PMID: 36795699 Free PMC article.

Peuker K, Strigli A, Tauriello DVF, Hendricks A, von Schönfels W, Burmeister G, Brosch M, Herrmann A, Krüger S, Nitsche J, Južnić L, Geissler MM, Hiergeist A, Gessner A, Wirbel J, Ponnudurai RP, Tunger A, Wehner R, Stange DE, Weitz J, Aust DE, Baretton GB, Schmitz M, Röcken C, Hampe J, Hinz S, Zeller G, Chavakis T, Schafmayer C, Batlle E, Zeissig S.
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
Immunity. 2022 Apr 12;55(4):701-717.e7. doi: 10.1016/j.immuni.2022.03.008. Epub 2022 Mar 31.PMID: 35364006

Ghimire S, Weber D, Hippe K, Meedt E, Hoepting M, Kattner AS, Hiergeist A, Gessner A, Matos C, Ghimire S, Wolff D, Edinger M, Hoffmann P, Poeck H, Herr W, Holler E.
GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics.
Front Immunol. 2021 Oct 28;12:753287. doi: 10.3389/fimmu.2021.753287. eCollection 2021.PMID: 34777363 Free PMC article.

Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M.
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
Sci Immunol. 2021 Nov 5;6(65):eabf7235. doi: 10.1126/sciimmunol.abf7235. Epub 2021 Nov 5.PMID: 34739338

Peuker, K., Strigli, A., Tauriello, D. V. F., Hendricks, A., von Schönfels, W., Burmeister, G., Brosch, M., Herrmann, A., Krüger, S., Nitsche, J., Južnić, L., Geissler, M. M., Hiergeist, A., Gessner, A., Wirbel, J., Ponnudurai, R. P., Tunger, A., Wehner, R., Stange, D. E., Weitz, J., Aust, D. E., Baretton, G. B., Schmitz, M., Röcken, C., Hampe, J., Hinz, S., Zeller, G., Chavakis, T., Schafmayer, C., Batlle, E. and Zeissig, S. (2022), 'Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.', Immunity.

Meedt, E., Hiergeist, A., Gessner, A., Dettmer, K., Liebisch, G., Ghimire, S., Poeck, H., Edinger, M., Wolff, D., Herr, W., Holler, E. and Weber, D. (2022), 'Prolonged Suppression of Butyrate-Producing Bacteria Is Associated With Acute Gastrointestinal Graft-vs-Host Disease and Transplantation-Related Mortality After Allogeneic Stem Cell Transplantation.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 74, 614--621.

Ghazavi, F., Huysentruyt, J., De Coninck, J., Kourula, S., Martens, S., Hassannia, B., Wartewig, T., Divert, T., Roelandt, R., Popper, B., Hiergeist, A., Tougaard, P., Vanden Berghe, T., Joossens, M., Berx, G., Takahashi, N., Wahida, A. and Vandenabeele, P. (2022), 'Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.', Proceedings of the National Academy of Sciences of the United States of America 119.

Wahida, A., Müller, M., Hiergeist, A., Popper, B., Steiger, K., Branca, C., Tschurtschenthaler, M., Engleitner, T., Donakonda, S., De Coninck, J., Öllinger, R., Pfautsch, M. K., Müller, N., Silva, M., Usluer, S., Thiele Orberg, E., Böttcher, J. P., Pfarr, N., Anton, M., Slotta-Huspenina, J. B., Nerlich, A. G., Madl, T., Basic, M., Bleich, A., Berx, G., Ruland, J., Knolle, P. A., Rad, R., Adolph, T. E., Vandenabeele, P., Kanegane, H., Gessner, A., Jost, P. J. and Yabal, M. (2021), 'XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.', Science immunology 6, eabf7235.

Basic, M., Bolsega, S., Smoczek, A., Gläsner, J., Hiergeist, A., Eberl, C., Stecher, B., Gessner, A. and Bleich, A. (2021), 'Monitoring and contamination incidence of gnotobiotic experiments performed in microisolator cages.', International journal of medical microbiology : IJMM 311, 151482.

Ghimire, S., Weber, D., Hippe, K., Meedt, E., Hoepting, M., Kattner, A.-S., Hiergeist, A., Gessner, A., Matos, C., Ghimire, S., Wolff, D., Edinger, M., Hoffmann, P., Poeck, H., Herr, W. and Holler, E. (2021), 'GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics.', Frontiers in immunology 12, 753287.

de Castilhos, J., Zamir, E., Hippchen, T., Rohrbach, R., Schmidt, S., Hengler, S., Schumacher, H., Neubauer, M., Kunz, S., Müller-Esch, T., Hiergeist, A., Gessner, A., Khalid, D., Gaiser, R., Cullin, N., Papagiannarou, S. M., Beuthien-Baumann, B., Krämer, A., Bartenschlager, R., Jäger, D., Müller, M., Herth, F., Duerschmied, D., Schneider, J., Schmid, R. M., Eberhardt, J. F., Khodamoradi, Y., Vehreschild, M. J. G. T., Teufel, A., Ebert, M. P., Hau, P., Salzberger, B., Schnitzler, P., Poeck, H., Elinav, E., Merle, U. and Stein-Thoeringer, C. K. (2021), 'Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Schwarz, S. R., Hirsch, S., Hiergeist, A., Kirschneck, C., Muehler, D., Hiller, K.-A., Maisch, T., Al-Ahmad, A., Gessner, A., Buchalla, W. and Cieplik, F. (2021), 'Limited antimicrobial efficacy of oral care antiseptics in microcosm biofilms and phenotypic adaptation of bacteria upon repeated exposure.', Clinical oral investigations 25, 2939--2950.

Lubnow, M., Schmidt, B., Fleck, M., Salzberger, B., Müller, T., Peschel, G., Schneckenpointner, R., Lange, T., Hitzenbichler, F., Kieninger, M., Lunz, D., Graf, B., Brochhausen, C., Weber, F., Lüke, Cieplik, F., Wiedenhofer, A. M., Pietsch, V., Hiller, K.-A., Hiergeist, A., Wagner, A., Baldaranov, D., Linker, R. A., Jantsch, J., Buchalla, W., Schlachetzki, F. and Gessner, A. (2020), 'Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia-A Prospective Observational Study.', Frontiers in neurology 11, 528056.

Hiergeist, A., Gessner, J. and Gessner, A. (2020), 'Current Limitations for the Assessment of the Role of the Gut Microbiome for Attention Deficit Hyperactivity Disorder (ADHD).', Frontiers in psychiatry 11, 623.

Bülow, S., Heyd, R., Toelge, M., Ederer, K. U., Schweda, A., Blaas, S. H., Hamer, O. W., Hiergeist, A., Wenzel, J. J. and Gessner, A. (2020), 'Lipopolysaccharide Binding Protein and Bactericidal/Permeability-Increasing Protein as Biomarkers for Invasive Pulmonary Aspergillosis.', Journal of fungi (Basel, Switzerland) 6.

Berger, F. K., Mellmann, A., von Müller, L., Bischoff, M., Gärtner, B. C. and speaking C. difficile laboratory study group, G. (2020),
'Quality assurance for genotyping and resistance testing of Clostridium (Clostridioides) difficile isolates - Experiences from the first inter-laboratory ring trial in four German speaking countries.',Anaerobe 61, 102093.

Schmidtner, A. K., Slattery, D. A., Gläsner, J., Hiergeist, A., Gryksa, K., Malik, V. A., Hellmann-Regen, J., Heuser, I., Baghai, T. C., Gessner, A., Rupprecht, R., Di Benedetto, B. and Neumann, I. D. (2019), 'Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner.', Translational psychiatry 9, 223.

Weber, D., Hiergeist, A., Weber, M., Dettmer, K., Wolff, D., Hahn, J., Herr, W., Gessner, A. and Holler, E. (2019), 'Detrimental Effect of Broad-spectrum Antibiotics on Intestinal Microbiome Diversity in Patients After Allogeneic Stem Cell Transplantation: Lack of Commensal Sparing Antibiotics.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 68, 1303--1310.

Hiergeist, A. and Gessner, A. (2018), '[The human intestinal microbiome and why you have to think twice before prescribing antibiotics!]', MMW Fortschritte der Medizin 160, 58--62.

Brenner, D., Hiergeist, A., Adis, C., Mayer, B., Gessner, A., Ludolph, A. C. and Weishaupt, J. H. (2018), 'The fecal microbiome of ALS patients.', Neurobiology of aging 61, 132--137.

Hiergeist, A. and Gessner, A. (2017), 'Clinical implications of the microbiome in urinary tract diseases.', Current opinion in urology 27, 93--98.

Weber, D., Frauenschläger, K., Ghimire, S., Peter, K., Panzer, I., Hiergeist, A., Weber, M., Kutny, D., Wolff, D., Grube, M., Huber, E., Oefner, P., Gessner, A., Hehlgans, T., Herr, W. and Holler, E. (2017), 'The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation.', PloS one 12, e0185265.

Simon, M., Melzl, H., Hiergeist, A., Richert, K., Falgenhauer, L., Pfeifer, Y., Gerlach, R. G., Fuchs, K., Reischl, U., Gessner, A. and Jantsch, J. (2017), 'Colistin- and carbapenem-resistant Klebsiella oxytoca harboringblaVIM-2 and an insertion in the mgrB gene isolated from blood culture', International journal of medical microbiology : IJMM 307, 113--115.

Weber, D., Jenq, R. R., Peled, J. U., Taur, Y., Hiergeist, A., Koestler, J., Dettmer, K., Weber, M., Wolff, D., Hahn, J., Pamer, E. G., Herr, W., Gessner, A., Oefner, P. J., van den Brink, M. R. M. and Holler, E. (2017), 'Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.', Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, 845--852.

Bouazzaoui, A., Huber, E., Dan, A., Al-Allaf, F. A., Pfirstinger, J., Sprotte, G., Köstler, J., Hiergeist, A., Gessner, A., Herr, W. and Holler, E. (2017), 'Reduction of aGVHD using chicken antibodies directed against intestinal pathogens in a murine model.', Blood 129, 1052--1055.

Eigner, U., Hiergeist, A., Veldenzer, A., Rohlfs, M., Schwarz, R. and Holfelder, M. (2017), 'Evaluation of a new real-time PCR assay for the direct detection of diarrheagenic Escherichia coli in stool specimens.', Diagnostic microbiology and infectious disease 88, 12--16.

Kikhney, J., von Schöning, D., Steding, I., Schulze, J., Petrich, A., Hiergeist, A., Reischl, U., Moter, A. and Thomas, A. (2017), 'Is Ureaplasma spp. the leading causative agent of acute chorioamnionitis in women with preterm birth?', Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 23, 119.e1--119.e7.

Altenbuchinger, M., Rehberg, T., Zacharias, H. U., Stämmler, F., Dettmer, K., Weber, D., Hiergeist, A., Gessner, A., Holler, E., Oefner, P. J. and Spang, R. (2017), 'Reference point insensitive molecular data analysis.', Bioinformatics (Oxford, England) 33, 219--226.

Hiergeist, A., Reischl, U., quality assessment participants , P. P. 1656. I. M. C. and Gessner, A. (2016), 'Multicenter quality assessment of 16S ribosomal DNA-sequencing for microbiome analyses reveals high inter-center variability.', International journal of medical microbiology : IJMM 306, 334--342.

Clavel, T., Lagkouvardos, I. and Hiergeist, A. (2016), 'Microbiome sequencing: challenges and opportunities for molecular medicine.', Expert review of molecular diagnostics 16, 795--805.

Stämmler, F., Gläsner, J., Hiergeist, A., Holler, E., Weber, D., Oefner, P. J., Gessner, A. and Spang, R. (2016), 'Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.', Microbiome 4, 28.

Kesselring, R., Glaesner, J., Hiergeist, A., Naschberger, E., Neumann, H., Brunner, S. M., Wege, A. K., Seebauer, C., Köhl, G., Merkl, S., Croner, R. S., Hackl, C., Stürzl, M., Neurath, M. F., Gessner, A., Schlitt, H.-J., Geissler, E. K. and Fichtner-Feigl, S. (2016), 'IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3.', Cancer cell 29, 684--696.

Krzyzak, L., Seitz, C., Urbat, A., Hutzler, S., Ostalecki, C., Gläsner, J., Hiergeist, A., Gessner, A., Winkler, T. H., Steinkasserer, A. and Nitschke, L. (2016), 'CD83 Modulates B Cell Activation and Germinal Center Responses.', Journal of immunology (Baltimore, Md. : 1950) 196, 3581--3594.

Weber, D., Oefner, P. J., Dettmer, K., Hiergeist, A., Koestler, J., Gessner, A., Weber, M., Stämmler, F., Hahn, J., Wolff, D., Herr, W. and Holler, E. (2016), 'Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation.', Bone marrow transplantation 51, 1087--1092.

Manook, A., Hiergeist, A., Rupprecht, R. and Baghai, T. C. (2016), '[Gut microbiome and major depressive disorder : The other side of ourselves].', Der Nervenarzt 87, 1227--1240.

Weber, D., Oefner, P. J., Hiergeist, A., Koestler, J., Gessner, A., Weber, M., Hahn, J., Wolff, D., Stämmler, F., Spang, R., Herr, W., Dettmer, K. and Holler, E. (2015), 'Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome.', Blood 126, 1723--1728.

Hiergeist, A., Gläsner, J., Reischl, U. and Gessner, A. (2015), 'Analyses of Intestinal Microbiota: Culture versus Sequencing.', ILAR journal 56, 228--240.