Wissenschaftliche Originalarbeiten der letzten Jahre

Plössl K, Straub K, Schmid V, Strunz F, Wild J, Merkl R, Weber BHF, Friedrich U1 (2019) Identification of the retinoschisin-binding site on the retinal Na/K-ATPase. PLoS One 14(5):e0216320. PMID: 31048931

Bülow S, Zeller L, Werner M, Toelge M, Holzinger J, Entzian C, Schubert T, Waldow F, Gisch N, Hammerschmidt S, Gessner A (2018) Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition. Front Immunol 9:2768, PMID: 30581431

Brandstetter S, Toncheva AA, Niggel J, Wolff C, Gran S, Seelbach-Göbel B, Apfelbacher C, Melter M, Kabesch M; KUNO-Kids study group; Collaborators: Arndt P, Baessler A, Berneburg M, Buchalla W, Fill Malfertheiner S, Gessner A, Heid I, Kerzel S, Koller M, Leitzmann M, Rothfuß D, Rösch W, Segerer H, Weber BHF, Weidinger S (2018) KUNO-Kids birth cohort study: rationale, design, and cohort description. Mol Cell Pediatr 6(1):1, PMID: 30627823

Simon M, Gatermann S, Pfeifer Y, Reischl U, Gessner A, Jantsch J (2018) Evaluation of the automated BD Phoenix CPO Detect panel in combination with the β-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales. J Microbiol Methods 156:29-33, PMID: 30521867

Weber D, Hiergeist A, Weber M, Dettmer K, Wolff D, Hahn J, Herr W, Gessner A, Holler E (2018) Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics. Clin Infect Dis [Epub ahead of print], PMID: 30124813

Zach F, Polzer F, Mueller A, Gessner A (2018) p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice. J Biol Chem 293(24):9530-9541, PMID: 29555685

Hösl J, Gessner A, El-Najjar N (2018) Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma. J Pharm Biomed Anal 157:92-99, PMID: 29777985

Simon M, Richert K, Pfennigwerth N, Pfeifer Y, Reischl U, Gatermann S, Gessner A, Jantsch J (2018) Carbapenemase detection using the β-CARBA test: Influence of test conditions on performance and comparison with the RAPIDEC CarbaNP assay. J Microbiol Methods 147:17-19, PMID: 29427685

Hiergeist A, Gessner A (2018) The human intestinal microbiome and why you have to think twice before prescribing antibiotics! MMW Fortschr Med 160(1):58-62, PMID: 29335940

Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH (2018) The fecal microbiome of ALS patients. Neurobiol Aging 61:132-137 PMID: 29065369

Dilger T, Melzl H, Gessner A (2017) Legionella contamination in warm water systems: A species-level survey. Int J Hyg Environ Health S1438-4639(17)30535-7, PMID: 29108681

Dietze-Schwonberg K, Lorenz B, Lopez Kostka S, Schumak B, Gessner A, von Stebut E (2017) Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis. Exp Dermatol, PMID: 29078003

Weber D, Frauenschläger K, Ghimire S, Peter K, Panzer I, Hiergeist A, Weber M, Kutny D, Wolff D, Grube M, Huber E, Oefner P, Gessner A, Hehlgans T, Herr W, Holler E (2017) The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation. PLoS One 12(9):e0185265, PMID: 28934349

Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J (2017) Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 114(13):E2766-E2775

El-Najjar N, Hösl J, Holzmann T, Jantsch J, Gessner A (2017) UPLC-MS/MS method for therapeutic drug monitoring of 10 antibiotics used in intensive care units. Drug Test Anal, PMID: 28753737

Lukas K, Stadtherr K, Gessner A, Wehner D, Schmid T, Wendel HP, Schmid C, Lehle K (2017) Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane. Materials (Basel) 10(4), PMID: 28772696

Naber KG, Kogan M, Wagenlehner FME, Siener R, Gessner A (2017) How the microbiome is influenced by the therapy of urological diseases: standard versus alternative approaches. Clinical Phytoscience 3:8

El-Najjar N, Jantsch J, Gessner A (2017) A rapid liquid chromatography-tandem mass spectrometry for the quantification of Fosfomycin in plasma, urine, and aqueous fluids. J Chromatogr B Analyt Technol Biomed Life Sci 1061-1062:57-64

Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J (2017) Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther 11:1729-1736. doi: 10.2147/DDDT.S138888

Plössl K, Royer M, Bernklau S, Tavraz NN, Friedrich T, Wild J, Weber BHF, Friedrich U (2017) Retinoschisin is linked to retinal Na/K-ATPase signaling and localization. Mol Biol Cell [Epub ahead of print] PMID: 28615319

Simon M, Held I, Teichmann L, Köstler J, Gessner A, Schmidt B, Jantsch J (2017) Liquillizer Does Not Interfere with Galactomannan Antigen Detection in Contrast to Dithiothreitol and N-Acetyl-l-Cysteine. J Clin Microbiol 55(6):1964-1965; PMID: 28381606

Weber D, Jenq RR, Peled JU, Taur Y, Hiergeist A, Koestler J, Dettmer K, Weber M, Wolff D, Hahn J, Pamer EG, Herr W, Gessner A, Oefner PJ, van den Brink MR, Holler E (2017) Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant 23(5):845-852; PMID: 28232086

Simon M, Melzl H, Hiergeist A, Richert K, Falgenhauer L, Pfeifer Y, Gerlach RG, Fuchs K, Reischl U, Gessner A, Jantsch J (2017) Colistin- and carbapenem-resistant Klebsiella oxytoca harboring blaVIM-2 and an insertion in the mgrB gene isolated from blood culture. Int J Med Microbiol 307(2):113-115; PMID: 28122677

El-Najjar N, Jantsch J, Gessner A (2017) The use of liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of antibiotics in cancer patients. Clin Chem Lab Med; PMID: 28076304

Bouazzaoui A, Huber E, Dan A, Al-Allaf FA, Pfirstinger J, Sprotte G, Köstler J, Hiergeist A, Gessner A, Herr W, Holler E (2016) Reduction of aGvHD using chicken antibodies directed against intestinal pathogens in a murine model. Blood; PMID: 28011676

Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff JM, Colegio OR, Bogdan C, Jantsch J (2016) Myeloid Cell-Derived HIF-1α Promotes Control of Leishmania major. J Immunol 197(10):4034-4041; PMID: 27798163

Hiergeist A, Gessner A (2016) Clinical implications of the microbiome in urinary tract diseases. Curr Opin Urol; PMID: 27898455

Altenbuchinger M, Rehberg T, Zacharias HU, Stämmler F, Dettmer K, Weber D, Hiergeist A, Gessner A, Holler E, Oefner PJ, Spang R (2016) Reference point insensitive molecular data analysis. Bioinformatics; PMID: 27634945

Weber D, Oefner PJ, Dettmer K, Hiergeist A, Koestler J, Gessner A, Weber M, Stämmler F, Hahn J, Wolff D, Herr W, Holler E (2016) Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant 51(8):1087-92; PMID: 26999466

Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R (2016) Adjusting microbiome profiles for differences in microbial load by spike-in bacteria. Microbiome 4:28; DOI 10.1186/s40168-016-0175-0

Dilger T, Melzl H, Gessner A (2016) Rapid and reliable identification of waterborne Legionella species by MALDI-TOF mass spectrometry. J Microbiol Methods 127 pp 154-159; PMID: 27260989

Pinkenburg O, Meyer T, Bannert N, Norley S, Bolte K, Czudai-Matwich V, Herold S, Gessner A, Schnare M (2016) The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus. PLoS One 6;11(6):e0156929; PMID: 27273104

Hiergeist A, Reischl U, Priority Program 1656 Intestinal Microbiota Consortium/quality assessment participants, Gessner A(2016) Multicenter quality assessment of 16S ribosomal DNA-sequencing formicrobiome analyses reveals high inter-center variability. Int J Med Microbiol; PMID: 27052158

Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L (2016) CD83 Modulates B Cell Activation and Germinal Center Responses. J Immunol; PMID: 26983787

Weber D, Oefner PJ, Dettmer K, Hiergeist A, Koestler J, Gessner A, Weber M, Stämmler F, Hahn J, Wolff D, Herr W, Holler E (2016) Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant; PMID: 26999466

Kesselring R, Glaesner J, Hiergeist A, Naschberger E, Neumann H, Brunner SM, Wege AK, Seebauer C, Köhl G, Merkl S, Croner RS, Hackl C, Stürzl M, Neurath MF, Gessner A, Schlitt HJ, Geissler EK, Fichtner-Feigl S (2016) IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Cancer Cell, available online 14 April 2016; doi:10.1016/j.ccell.2016.03.014

Dilger T, Melzl H, Gessner A (2016) Legionellen-Kontaminationen in Warmwassersystemen in Deutschland - Einfluss der maximal erreichbaren Temperatur und der Temperatur bei der Probenahme. gwf-Wasser/Abwasser, Ausgabe 03 2016

Lukas K, Thomas U, Gessner A, Wehner D, Schmid T, Schmid C, Lehle K (2016) Plasma functionalization of polycarbonaturethane to improve endothelialization—Effect of shear stress as a critical factor for biocompatibility control. Journal of Biomaterials Applications, Published online before print January 12, 2016, PMID: 26762398
Zach F, Mueller A, Gessner A (2015) Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells. PLoS ONE 10:e0142211; PMID: 26529319

Hiergeist A, Gläsner J, Reischl U, Gessner A (2015) Analyses of Intestinal Microbiota: Culture versus Sequencing. ILAR J 56(2):228-40; PMID: 26323632

Weber D, Oefner PJ, Hiergeist A, Koestler J, Gessner A, Weber M, Hahn J, Wolff D, Stämmler F, Spang R, Herr W, Dettmer K, Holler E (2015) Low urinary indoxyl sulfate levels early after ASCT reflect a disrupted microbiome and are associated with poor outcome. Blood 24 [Epub ahead of print]; PMID: 26209659

Knop J, Hanses F, Leist T, Archin NM, Buchholz S, Gläsner J, Gessner A, Wege AK (2015) Staphylococcus aureus Infection in Humanized Mice: A New Model to Study Pathogenicity Associated With Human Immune Response. J Infect Dis pii: jiv073 [Epub ahead of print]; PMID: 25657257

Holler E, Butzhammer P, Schmid K, Hundsrucker C, Koestler J, Peter K, Zhu W, Sporrer D, Hehlgans T, Kreutz M, Holler B, Wolff D, Edinger M, Andreesen R, Levine JE, Ferrara JL, Gessner A, Spang R, Oefner PJ (2014) Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease. Biol Blood Marrow Transplant 20(5):640-5; PMID: 24492144

Goldwich A, Burkard M, Ölke M, Daniel C, Amann K, Hugo C, Kurts C, Steinkasserer A, Gessner A (2013) Podocytes are nonhematopoietic professional antigen-presenting cells. J Am Soc Nephrol 24(6):906-16; PMID: 23539760

Goldwich A, Steinkasserer A, Gessner A, Amann K (2012) Impairment of podocyte function by diphtheria toxin-a new reversible proteinuria model in mice. Lab Invest 92:1674-85; PMID: 23007132

Rückert C, Licht K, Kalinowski J, Espírito Santo C, Antwerpen M, Hanczaruk M, Reischl U, Holzmann T, Gessner A, Tiemann C, Grass G (2012) Draft Genome Sequence of Bacillus anthracis UR-1, Isolated from a German Heroin User. J Bacteriol 194:5997-8; PMID: 23045504

Holzmann T, Frangoulidis D, Simon M, Noll P, Schmoldt S, Hanczaruk M, Grass G, Pregler M, Sing A, Hörmansdorfer S, Bernard H, Grunow R, Zimmermann R, Schneider-Brachert W, Gessner A, Reischl U (2012) Fatal anthrax infection in a heroin user from southern Germany, June 2012. Euro Surveill 17; PMID: 22790532

Sitte S, Gläsner J, Jellusova J, Weisel F, Panattoni M, Pardi R, Gessner A (2012) JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression. J Immunol 188:2677-86; PMID: 22327073

Böckl K, Wild J, Bredl S, Kindsmüller K, Köstler J, Wagner R (2012) Altering an artificial GagPolNef polyprotein and mode of Env co-administration affects the immunogenicity of a clade C HIV DNA vaccine. PLoS ONE 7:e34723; PMID: 22509350

Klaffenbach D, Friedrich D, Strick R, Strissel PL, Beckmann MW, Rascher W, Gessner A, Dötsch J, Meissner U, Schnare M (2011) Contribution of different placental cells to the expression and stimulation of antimicrobial proteins (AMPs). Placenta 32:830-7

Agwale SM, Forbi JC, Notka F, Wrin T, Wild J, Wagner R, Wolf H (2011) Broad Antibody Mediated Cross-Neutralization and Preclinical Immunogenicity of New Codon-Optimized HIV-1 Clade CRF02_AG and G Primary Isolates. PLoS One 6:e23233

Schulze J, Bickert T, Beil FT, Zaiss MM, Albers J, Wintges K, Streichert T, Klaetschke K, Keller J, Hissnauer TN, Spiro AS, Gessner A, Schett G, Amling M, McKenzie AN, Horst AK, Schinke T (2011) Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells. J Bone Miner Res 26:704-17

Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol 90:551-62

First description of cytokine Elispot technique

Gessner A, Moskophidis D, Lehmann-Grube F (1989) Enumeration of single interferon-gamma producing cells in mice during viral and bacterial infection. J Immunol 142:1293-9