Research Group Prof. Dr. Dr. André Gessner
Phone | +49 (0) 941 - 944 6400 | ||||
Fax | +49 (0) 941 - 944 6402 | ||||
andre.gessner@ukr.de | |||||
Our Projects
All current projects of our research group at a glance: :
Characterization of bactericidal/permeability increasing protein expression and function based on newly developed transgenic mouse models
Bactericidal/permeability increasing protein (BPI) belongs to the highly conserved family of lipid-transfer-proteins. BPI is synthesized early during myelopoiesis by granulocyte … Read more Characterization of bactericidal/permeability increasing protein expression and function based on newly developed transgenic mouse models
MITARBEITER
Hier finden Sie den richtigen Ansprechpartner:
UNSERE NEWS
Alle aktuellen News unserer Arbeitsgruppe auf einen Blick:
Thiele Orberg E, Meedt E, Hiergeist A, Xue J, Heinrich P, Ru J, Ghimire S, Miltiadous O, Lindner S, Tiefgraber M, Göldel S, Eismann T, Schwarz A, Göttert S, Jarosch S, Steiger K, Schulz C, Gigl M, Fischer JC, Janssen KP, Quante M, Heidegger S, Herhaus P, Verbeek M, Ruland J, van den Brink MRM, Weber D, Edinger M, Wolff D, Busch DH, Kleigrewe K, Herr W, Bassermann F, Gessner A, Deng L, Holler E, Poeck H.
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation.
Nat Cancer. 2024 Jan 3. doi: 10.1038/s43018-023-00669-x. Online ahead of print.PMID: 38172339
Mao X, Hiergeist A, Auer DL, Scholz KJ, Muehler D, Hiller KA, Maisch T, Buchalla W, Hellwig E, Gessner A, Al-Ahmad A, Cieplik F. Ecological Effects of Daily Antiseptic Treatment on Microbial Composition of Saliva-Grown Microcosm Biofilms and Selection of Resistant Phenotypes.
Front Microbiol. 2022 Jun 30;13:934525. doi: 10.3389/fmicb.2022.934525. eCollection 2022.PMID: 35847089 Free PMC article.
Stumptner C, Stadlbauer V, O'Neil D, Gessner A, Hiergeist A, Zatloukal K, Abuja PM.The Pre-Analytical CEN/TS Standard for Microbiome Diagnostics-How Can Research and Development Benefit? Nutrients. 2022 May 9;14(9):1976. doi: 10.3390/nu14091976.PMID: 35565946 Free PMC article.
de Castilhos J, Zamir E, Hippchen T, Rohrbach R, Schmidt S, Hengler S, Schumacher H, Neubauer M, Kunz S, Müller-Esch T, Hiergeist A, Gessner A, Khalid D, Gaiser R, Cullin N, Papagiannarou SM, Beuthien-Baumann B, Krämer A, Bartenschlager R, Jäger D, Müller M, Herth F, Duerschmied D, Schneider J, Schmid RM, Eberhardt JF, Khodamoradi Y, Vehreschild MJGT, Teufel A, Ebert MP, Hau P, Salzberger B, Schnitzler P, Poeck H, Elinav E, Merle U, Stein-Thoeringer CK. Correction to: Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients. Clin Infect Dis. 2022 May 10:ciac254. doi: 10.1093/cid/ciac254. Online ahead of print.PMID: 35536665 No abstract available.
Agamennone V, Abuja PM, Basic M, De Angelis M, Gessner A, Keijser B, Larsen M, Pinart M, Nimptsch K, Pujos-Guillot E, Schlicht K, Sharon I, Untersmayr E, Laudes M, Pischon T, Bouwman J, On Behalf Of The Consortium. HDHL-INTIMIC: A European Knowledge Platform on Food, Diet, Intestinal Microbiomics, and Human Health.
Nutrients. 2022 Apr 29;14(9):1881. doi: 10.3390/nu14091881.PMID: 35565847 Free PMC article.
Ghimire S, Ederer KU, Meedt E, Weber D, Matos C, Hiergeist A, Zeman F, Wolff D, Edinger M, Poeck H, Herr W, Gessner A, Holler E, Bülow S. Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation.
Front Immunol. 2022 Apr 29;13:857400. doi: 10.3389/fimmu.2022.857400. eCollection 2022.PMID: 35572572 Free PMC article.
Meister TL, Gottsauner JM, Schmidt B, Heinen N, Todt D, Audebert F, Buder F, Lang H, Gessner A, Steinmann E, Vielsmeier V, Pfaender S, Cieplik F. Mouthrinses against SARS-CoV-2 - High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial. Virus Res. 2022 Jul 15;316:198791. doi: 10.1016/j.virusres.2022.198791. Epub 2022 May 2.PMID: 35504446 Free PMC article. Clinical Trial.
Glück V, Tydykov L, Mader AL, Warda AS, Bertok M, Weidlich T, Gottwald C, Köstler J, Salzberger B, Wagner R, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D.Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19-convalescent subjects. Infection. 2022 Apr 11:1-7. doi: 10.1007/s15010-022-01817-8. Online ahead of print.PMID: 35403960 Free PMC article.
Mader AL, Tydykov L, Glück V, Bertok M, Weidlich T, Gottwald C, Stefl A, Vogel M, Plentz A, Köstler J, Salzberger B, Wenzel JJ, Niller HH, Jantsch J, Wagner R, Schmidt B, Glück T, Gessner A, Peterhoff D. Omicron’s binding to Sotrovimab, Casirivimab, Imdevimab, CR3022, and sera from previously infected or vaccinated individuals. iScience. 2022 Mar 14:104076. doi: 10.1016/j.isci.2022.104076. Online ahead of print.PMID: 35309727 Free PMC article.
Peuker K; Strigli A, Tauriello D F V, Hendricks A, von Schönfels W, Burmeister G, Brosch M, Herrmann A, Krüger S, Nitsche J, Južnić L, Geissler M M, Hiergeist A, Gessner A, Wirbel M, Ponnudurai R P, Tunger A, Wehner R, Stange D E, Weitz J, Aust D E, Baretton G B, Schmitz M, Röcken C, Hampe J, Hinz S, Zeller G, Chavakis T, Schafmayer C, Batlle E, Zeissig S. Integration of microbial signals by myeloid calcineurin controls anti-tumor immunity in colorectal cancer. Immunity, 2022, in press.
Peterhoff D, Einhauser S, Beileke S, Niller HH, Günther F, Schachtner M, Asbach B, Steininger P, Tenbusch M, Peter AS, Gessner A, Burkhardt R, Heid IM, Wagner R, Überla K. Comparative Immunogenicity of COVID-19 Vaccines in a Population-Based Cohort Study with SARS-CoV-2-Infected and Uninfected Participants. Vaccines (Basel). 2022 Feb 18;10(2):324.
Schneider F, Gessner A, El-Najjar N. Efficacy of Vancomycin and Meropenem in Central Nervous System Infections in Children and Adults: Current Update. Antibiotics (Basel). 2022 Jan 28;11(2):173.
Ederer KU, Holzinger JM, Maier KT, Zeller L, Werner M, Toelge M, Gessner A, Bülow S. A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide.Int J Mol Sci. 2022 Jan 25;23(3):132
Neumann B, Angstwurm K, Linker RA, Knoll G, Eidenschink L, Rubbenstroth D, Schlottau K, Beer M, Schreiner P, Soutschek E, Böhmer MM, Lampl BMJ, Pregler M, Scheiter A, Evert K, Zoubaa S, Riemenschneider MJ, Asbach B, Gessner A, Niller HH, Schmidt B, Bauswein M. Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections. Cell Rep Med. 2022 Jan 18;3(1):100499
Pfab C, Abgaryan A, Danzer B, Mourtada F, Ali W, Gessner A, El-Najjar N . Ceftazidime and cefepime antagonize 5-fluorouracil's effect in colon cancer cells. BMC Cancer. 2022 Jan 31;22(1):125
Bauswein M, Peterhoff D, Plentz A, Hiergeist A, Wagner R, Gessner A, Salzberger B, Schmidt B, Bauernfeind S. Increased neutralization of SARS-CoV-2 Delta variant after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination. iScience. 2022 Feb 18;25(2):103694,
Hupf J, Burkhardt R, Gessner A, Maier-Stocker C, Zimmermann M, Hanses F, Peterhoff D. Low incidence of SARS-CoV-2 infections in healthcare workers at a tertiary care hospital : Results of a prospective serological cohort study of the first and second COVID 19 pandemic wave. Med Klin Intensivmed Notfallmed. 2022 Jan 3:1-5.
Lang S, Loibl M, Gläsner J, Simon M, Rupp M, Grad S, Neumann C, Alt V, Gessner A, Hanses F. Vertebral osteomyelitis is characterised by increased RANK/OPG and RANKL/OPG expression ratios in vertebral bodies and intervertebral discs. Eur Cell Mater. 2021 Nov 29;42:438-451.
Schuderer JG, Spörl S, Spanier G, Gottsauner M, Gessner A, Hitzenbichler F, Meier JK, Reichert TE, Ettl T. Surgical and remote site infections after reconstructive surgery of the head and neck: A risk factor analysis. Craniomaxillofac Surg. 2022 Feb;50(2):178-187.
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K. Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone. J Clin Invest. 2021 Nov 15;131(22):e148225.
Ghimire S, Weber D, Hippe K, Meedt E, Hoepting M, Kattner AS, Hiergeist A, Gessner A, Matos C, Wolff D, Edinger M, Hoffmann P, Poeck H, Herr W, Holler E GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. Front Immunol. 2021 Oct 28;12:753287
Hottenträger B, Hagedorn HJ, Bäcker E, Bleekmann B, Gessner A, Lübke N, Wenzel JJ, Widera M, Pabinger S, Ramge P, Timm J Multicenter Performance Evaluation of Elecsys Anti-HBc II, Anti-HCV II, HIV combi PT, HBsAg II, and Syphilis Immunoassays. Clin Lab. 2021 Nov 1;67(11).
Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M. XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells. Sci Immunol. 2021 Nov 5;6(65):eabf7235
Bauernfeind S, Salzberger B, Hitzenbichler F, Scigala K, Einhauser S, Wagner R, Gessner A, Koestler J, Peterhoff D. Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2 Vaccines (Basel). 2021 Sep 27;9(10):1089.
.de Castilhos J, Zamir E, Hippchen T, Rohrbach R, Schmidt S, Hengler S, Schumacher H, Neubauer M, Kunz S, Müller-Esch T, Hiergeist A, Gessner A, Khalid D, Gaiser R, Cullin N, Papagiannarou SM, Beuthien-Baumann B, Krämer A, Bartenschlager R, Jäger D, Müller M, Herth F, Duerschmied D, Schneider J, Schmid RM, Eberhardt JF, Khodamoradi Y, Vehreschild MJGT, Teufel A, Ebert MP, Hau P, Salzberger B, Schnitzler P, Poeck H, Elinav E, Merle U, Stein-Thoeringer CK Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients. Clin Infect Dis. 2021 Oct 25:ciab902.
Glück V, Grobecker S, Köstler J, Tydykov L, Bertok M, Weidlich T, Gottwald C, Salzberger B, Wagner R, Zeman F, Koller M, Gessner A, Schmidt B, Glück T, Peterhoff D Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel. Infection. 2021 Sep 25:1-8
Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, Thomas LF, Rasheed H, Rowan BX, Graham SE, Vanderweff BR, Patil SB; VA Million Veteran Program, Robinson-Cohen C, Gaziano JM, O'Donnell CJ, Willer CJ, Hallan S, Åsvold BO, Gessner A, Hung AM, Pattaro C, Köttgen A, Stark KJ, Heid IM, Winkler TW. Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals Nat Commun. 2021 Jul 16;12(1):4350.
Pfab C, Schnobrich L, Eldnasoury S, Gessner A, El-Najjar N Repurposing of Antimicrobial Agents for Cancer Therapy: What Do We Know? Cancers (Basel). 2021 Jun 26;13(13):3193.
Wagner R, Peterhoff D, Beileke S, Günther F, Berr M, Einhauser S, Schütz A, Niller HH, Steininger P, Knöll A, Tenbusch M, Maier C, Korn K, Stark KJ, Gessner A, Burkhardt R, Kabesch M, Schedl H, Küchenhoff H, Pfahlberg AB, Heid IM, Gefeller O, Überla K. Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020. Viruses. 2021 Jun 10;13(6):1118
Renner K, Schwittay T, Chaabane S, Gottschling J, Müller C, Tiefenböck C, Salewski JN, Winter F, Buchtler S, Balam S, Malfertheiner MV, Lubnow M, Lunz D, Graf B, Hitzenbichler F, Hanses F, Poeck H, Kreutz M, Orsó E, Burkhardt R, Niedermair T, Brochhausen C, Gessner A, Salzberger B, Mack M. Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes. Nat Commun. 2021 May 21;12(1):3006
Meedt E, Hiergeist A, Gessner A, Dettmer K, Liebisch G, Ghimire S, Poeck H, Edinger M, Wolff D, Herr W, Holler E, Weber D Prolonged Suppression of Butyrate-Producing Bacteria Is Associated With Acute Gastrointestinal Graft-vs-Host Disease and Transplantation-Related Mortality After Allogeneic Stem Cell Transplantation Clin Infect Dis. 2022 Mar 1;74(4):614-621
Mao X, Jakubovics NS, Bächle M, Buchalla W, Hiller KA, Maisch T, Hellwig E, Kirschneck C, Gessner A, Al-Ahmad A, Cieplik F. Colonization of Helicobacter pylori in the oral cavity - an endless controversy? Crit Rev Microbiol. 2021 Sep;47(5):612-629.
Glück V, Grobecker S, Tydykov L, Salzberger B, Glück T, Weidlich T, Bertok M, Gottwald C, Wenzel JJ, Gessner A, Schmidt B, Peterhoff D. SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19. Infection. 2021 Aug;49(4):739-746.
Basic M, Bolsega S, Smoczek A, Gläsner J, Hiergeist A, Eberl C, Stecher B, Gessner A, Bleich . Monitoring and contamination incidence of gnotobiotic experiments performed in microisolator cages. Int J Med Microbiol. 2021 Apr;311(3):151482
Evert K, Dienemann T, Brochhausen C, Lunz D, Lubnow M, Ritzka M, Keil F, Trummer M, Scheiter A, Salzberger B, Reischl U, Boor P, Gessner A, Jantsch J, Calvisi DF, Evert M, Schmidt B, Simon M. Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation. Virchows Arch. 2021 Jul;479(1):97-108.
Lubnow M, Schmidt B, Fleck M, Salzberger B, Müller T, Peschel G, Schneckenpointner R, Lange T, Hitzenbichler F, Kieninger M, Lunz D, Graf B, Brochhausen C, Weber F, Lüke F, Peterhoff D, Schuster P, Hiergeist A, Offner R, Hehr U, Wallner S, Hanses F, Schmid S, Weigand K, Geismann F, Poeck H, Pukrop T, Evert M, Gessner A, Burkhardt R, Herr W, Maier LS, Heudobler D. Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson's disease: Balancing immunosuppression. Int J Infect Dis. 2021 Feb;103:624-627
Hähnel V, Peterhoff D, Bäuerlein V, Brosig AM, Pamler I, Johnson C, Bica A, Totir M, Ossner T, Stemmer B, Toelge M, Schütz A, Niller HH, Schmidt B, Wagner R, Gessner A, Burkhard R, Offner R.I Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality. PLoS One. 2020 Dec 22;15(12):e0243967.
Cieplik F, Wiedenhofer AM, Pietsch V, Hiller KA, Hiergeist A, Wagner A, Baldaranov D, Linker RA, Jantsch J, Buchalla W, Schlachetzki F, Gessner A. Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia-A Prospective Observational Study. . Front Neurol 2020 Nov 6;11:528056.
Bülow S, Heyd R, Toelge M, Ederer KU, Schweda A, Blaas SH, Hamer OW, Hiergeist A, Wenzel JJ, Gessner A. Lipopolysaccharide Binding Protein and Bactericidal/Permeability-Increasing Protein as Biomarkers for Invasive Pulmonary Aspergillosis. J Fungi (Basel). 2020 Nov 20;6(4):304.
Lichtinger U, Greifenberg V, Gessner A. Antibiotic stewardship (ABS)-strategies for urologists in private practice and hospitals. Urologe A. 2020 Dec;59(12):1472-1479
Schwarz SR, Hirsch S, Hiergeist A, Kirschneck C, Muehler D, Hiller KA, Maisch T, Al-Ahmad A, Gessner A, Buchalla W, Cieplik FLimited antimicrobial efficacy of oral care antiseptics in microcosm biofilms and phenotypic adaptation of bacteria upon repeated exposure. Clin Oral Investig. 2021 May;25(5):2939-2950.
Peterhoff D, Glück V, Vogel M, Schuster P, Schütz A, Neubert P, Albert V, Frisch S, Kiessling M, Pervan P, Werner M, Ritter N, Babl L, Deichner M, Hanses F, Lubnow M, Müller T, Lunz D, Hitzenbichler F, Audebert F, Hähnel V, Offner R, Müller M, Schmid S, Burkhardt R, Glück T, Koller M, Niller HH, Graf B, Salzberger B, Wenzel JJ, Jantsch J, Gessner A, Schmidt B, Wagner R. A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization. Infection. 2021 Feb;49(1):75-82.
Hiergeist A, Gessner J, Gessner A. Current Limitations for the Assessment of the Role of the Gut Microbiome for Attention Deficit Hyperactivity Disorder (ADHD). Front Psychiatry. 2020 Jun 26;11:623.
Danzer H, Glaesner J, Baerenwaldt A, Reitinger C, Lux A, Heger L, Dudziak D, Harrer T, Gessner A, Nimmerjahn F. Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis. Elife. 2020 Jul 2;9:e55319
Stolte M, Ali W, Jänis J, Gessner A, El-Najjar N. Paclitaxel, Imatinib and 5-Fluorouracil Increase the Unbound Fraction of Flucloxacillin In Vitro. Antibiotics (Basel). 2020 Jun 8;9(6):309
Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat Commun. 2020 May 8;11(1):2306.
Pamler I, Richter E, Hutchinson JA, Hähnel V, Holler E, Gessner A, Burkhardt R, Ahrens N. Bacterial contamination rates in extracorporeal photopheresis. Transfusion. 2020 Jun;60(6):1260-1266.
Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med. 2020 Feb 27;382(9):822-834.
Niller HH, Angstwurm K, Rubbenstroth D, Schlottau K, Ebinger A, Giese S, Wunderlich S, Banas B, Forth LF, Hoffmann D, Höper D, Schwemmle M, Tappe D, Schmidt-Chanasit J, Nobach D, Herden C, Brochhausen C, Velez-Char N, Mamilos A, Utpatel K, Evert M, Zoubaa S, Riemenschneider MJ, Ruf V, Herms J, Rieder G, Errath M, Matiasek K, Schlegel J, Liesche-Starnecker F, Neumann B, Fuchs K, Linker RA, Salzberger B, Freilinger T, Gartner L, Wenzel JJ, Reischl U, Jilg W, Gessner A, Jantsch J, Beer M, Schmidt B. Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation. Lancet Infect Dis. 2020 Apr;20(4):467-477.
Plössl K, Straub K, Schmid V, Strunz F, Wild J, Merkl R, Weber BHF, Friedrich U1 (2019) Identification of the retinoschisin-binding site on the retinal Na/K-ATPase. PLoS One 14(5):e0216320. PMID: 31048931
Bülow S, Zeller L, Werner M, Toelge M, Holzinger J, Entzian C, Schubert T, Waldow F, Gisch N, Hammerschmidt S, Gessner A (2018) Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition. Front Immunol 9:2768, PMID: 30581431
Brandstetter S, Toncheva AA, Niggel J, Wolff C, Gran S, Seelbach-Göbel B, Apfelbacher C, Melter M, Kabesch M; KUNO-Kids study group; Collaborators: Arndt P, Baessler A, Berneburg M, Buchalla W, Fill Malfertheiner S, Gessner A, Heid I, Kerzel S, Koller M, Leitzmann M, Rothfuß D, Rösch W, Segerer H, Weber BHF, Weidinger S (2018) KUNO-Kids birth cohort study: rationale, design, and cohort description. Mol Cell Pediatr 6(1):1, PMID: 30627823
Simon M, Gatermann S, Pfeifer Y, Reischl U, Gessner A, Jantsch J (2018) Evaluation of the automated BD Phoenix CPO Detect panel in combination with the β-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales. J Microbiol Methods 156:29-33, PMID: 30521867
Weber D, Hiergeist A, Weber M, Dettmer K, Wolff D, Hahn J, Herr W, Gessner A, Holler E (2018) Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics. Clin Infect Dis [Epub ahead of print], PMID: 30124813
Zach F, Polzer F, Mueller A, Gessner A (2018) p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice. J Biol Chem 293(24):9530-9541, PMID: 29555685
Hösl J, Gessner A, El-Najjar N (2018) Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma. J Pharm Biomed Anal 157:92-99, PMID: 29777985
Simon M, Richert K, Pfennigwerth N, Pfeifer Y, Reischl U, Gatermann S, Gessner A, Jantsch J (2018) Carbapenemase detection using the β-CARBA test: Influence of test conditions on performance and comparison with the RAPIDEC CarbaNP assay. J Microbiol Methods 147:17-19, PMID: 29427685
Hiergeist A, Gessner A (2018) The human intestinal microbiome and why you have to think twice before prescribing antibiotics! MMW Fortschr Med 160(1):58-62, PMID: 29335940
Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH (2018) The fecal microbiome of ALS patients. Neurobiol Aging 61:132-137 PMID: 29065369
Dilger T, Melzl H, Gessner A (2017) Legionella contamination in warm water systems: A species-level survey. Int J Hyg Environ Health S1438-4639(17)30535-7, PMID: 29108681
Dietze-Schwonberg K, Lorenz B, Lopez Kostka S, Schumak B, Gessner A, von Stebut E (2017) Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis. Exp Dermatol, PMID: 29078003
Weber D, Frauenschläger K, Ghimire S, Peter K, Panzer I, Hiergeist A, Weber M, Kutny D, Wolff D, Grube M, Huber E, Oefner P, Gessner A, Hehlgans T, Herr W, Holler E (2017) The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation. PLoS One 12(9):e0185265, PMID: 28934349
Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J (2017) Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 114(13):E2766-E2775
El-Najjar N, Hösl J, Holzmann T, Jantsch J, Gessner A (2017) UPLC-MS/MS method for therapeutic drug monitoring of 10 antibiotics used in intensive care units. Drug Test Anal, PMID: 28753737
Lukas K, Stadtherr K, Gessner A, Wehner D, Schmid T, Wendel HP, Schmid C, Lehle K (2017) Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane. Materials (Basel) 10(4), PMID: 28772696
Naber KG, Kogan M, Wagenlehner FME, Siener R, Gessner A (2017) How the microbiome is influenced by the therapy of urological diseases: standard versus alternative approaches. Clinical Phytoscience 3:8
El-Najjar N, Jantsch J, Gessner A (2017) A rapid liquid chromatography-tandem mass spectrometry for the quantification of Fosfomycin in plasma, urine, and aqueous fluids. J Chromatogr B Analyt Technol Biomed Life Sci 1061-1062:57-64
Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J (2017) Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther 11:1729-1736. doi: 10.2147/DDDT.S138888
Plössl K, Straub K, Schmid V, Strunz F, Wild J, Merkl R, Weber BHF, Friedrich U1 (2019) Identification of the retinoschisin-binding site on the retinal Na/K-ATPase. PLoS One 14(5):e0216320. PMID: 31048931
Bülow S, Zeller L, Werner M, Toelge M, Holzinger J, Entzian C, Schubert T, Waldow F, Gisch N, Hammerschmidt S, Gessner A (2018) Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition. Front Immunol 9:2768, PMID: 30581431
Brandstetter S, Toncheva AA, Niggel J, Wolff C, Gran S, Seelbach-Göbel B, Apfelbacher C, Melter M, Kabesch M; KUNO-Kids study group; Collaborators: Arndt P, Baessler A, Berneburg M, Buchalla W, Fill Malfertheiner S, Gessner A, Heid I, Kerzel S, Koller M, Leitzmann M, Rothfuß D, Rösch W, Segerer H, Weber BHF, Weidinger S (2018) KUNO-Kids birth cohort study: rationale, design, and cohort description. Mol Cell Pediatr 6(1):1, PMID: 30627823
Simon M, Gatermann S, Pfeifer Y, Reischl U, Gessner A, Jantsch J (2018) Evaluation of the automated BD Phoenix CPO Detect panel in combination with the β-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales. J Microbiol Methods 156:29-33, PMID: 30521867
Weber D, Hiergeist A, Weber M, Dettmer K, Wolff D, Hahn J, Herr W, Gessner A, Holler E (2018) Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics. Clin Infect Dis [Epub ahead of print], PMID: 30124813
Zach F, Polzer F, Mueller A, Gessner A (2018) p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice. J Biol Chem 293(24):9530-9541, PMID: 29555685
Hösl J, Gessner A, El-Najjar N (2018) Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma. J Pharm Biomed Anal 157:92-99, PMID: 29777985
Simon M, Richert K, Pfennigwerth N, Pfeifer Y, Reischl U, Gatermann S, Gessner A, Jantsch J (2018) Carbapenemase detection using the β-CARBA test: Influence of test conditions on performance and comparison with the RAPIDEC CarbaNP assay. J Microbiol Methods 147:17-19, PMID: 29427685
Hiergeist A, Gessner A (2018) The human intestinal microbiome and why you have to think twice before prescribing antibiotics! MMW Fortschr Med 160(1):58-62, PMID: 29335940
Brenner D, Hiergeist A, Adis C, Mayer B, Gessner A, Ludolph AC, Weishaupt JH (2018) The fecal microbiome of ALS patients. Neurobiol Aging 61:132-137 PMID: 29065369
Dilger T, Melzl H, Gessner A (2017) Legionella contamination in warm water systems: A species-level survey. Int J Hyg Environ Health S1438-4639(17)30535-7, PMID: 29108681
Dietze-Schwonberg K, Lorenz B, Lopez Kostka S, Schumak B, Gessner A, von Stebut E (2017) Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis. Exp Dermatol, PMID: 29078003
Weber D, Frauenschläger K, Ghimire S, Peter K, Panzer I, Hiergeist A, Weber M, Kutny D, Wolff D, Grube M, Huber E, Oefner P, Gessner A, Hehlgans T, Herr W, Holler E (2017) The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation. PLoS One 12(9):e0185265, PMID: 28934349
Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J (2017) Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 114(13):E2766-E2775
El-Najjar N, Hösl J, Holzmann T, Jantsch J, Gessner A (2017) UPLC-MS/MS method for therapeutic drug monitoring of 10 antibiotics used in intensive care units. Drug Test Anal, PMID: 28753737
Lukas K, Stadtherr K, Gessner A, Wehner D, Schmid T, Wendel HP, Schmid C, Lehle K (2017) Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane. Materials (Basel) 10(4), PMID: 28772696
Naber KG, Kogan M, Wagenlehner FME, Siener R, Gessner A (2017) How the microbiome is influenced by the therapy of urological diseases: standard versus alternative approaches. Clinical Phytoscience 3:8
El-Najjar N, Jantsch J, Gessner A (2017) A rapid liquid chromatography-tandem mass spectrometry for the quantification of Fosfomycin in plasma, urine, and aqueous fluids. J Chromatogr B Analyt Technol Biomed Life Sci 1061-1062:57-64
Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, Benditz A, Springorum HR, Schaumburger J (2017) Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther 11:1729-1736. doi: 10.2147/DDDT.S138888
Plössl K, Royer M, Bernklau S, Tavraz NN, Friedrich T, Wild J, Weber BHF, Friedrich U (2017) Retinoschisin is linked to retinal Na/K-ATPase signaling and localization. Mol Biol Cell [Epub ahead of print] PMID: 28615319
Simon M, Held I, Teichmann L, Köstler J, Gessner A, Schmidt B, Jantsch J (2017) Liquillizer Does Not Interfere with Galactomannan Antigen Detection in Contrast to Dithiothreitol and N-Acetyl-l-Cysteine. J Clin Microbiol 55(6):1964-1965; PMID: 28381606
Weber D, Jenq RR, Peled JU, Taur Y, Hiergeist A, Koestler J, Dettmer K, Weber M, Wolff D, Hahn J, Pamer EG, Herr W, Gessner A, Oefner PJ, van den Brink MR, Holler E (2017) Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant 23(5):845-852; PMID: 28232086
Simon M, Melzl H, Hiergeist A, Richert K, Falgenhauer L, Pfeifer Y, Gerlach RG, Fuchs K, Reischl U, Gessner A, Jantsch J (2017) Colistin- and carbapenem-resistant Klebsiella oxytoca harboring blaVIM-2 and an insertion in the mgrB gene isolated from blood culture. Int J Med Microbiol 307(2):113-115; PMID: 28122677
El-Najjar N, Jantsch J, Gessner A (2017) The use of liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of antibiotics in cancer patients. Clin Chem Lab Med; PMID: 28076304
Bouazzaoui A, Huber E, Dan A, Al-Allaf FA, Pfirstinger J, Sprotte G, Köstler J, Hiergeist A, Gessner A, Herr W, Holler E (2016) Reduction of aGvHD using chicken antibodies directed against intestinal pathogens in a murine model. Blood; PMID: 28011676
Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff JM, Colegio OR, Bogdan C, Jantsch J (2016) Myeloid Cell-Derived HIF-1α Promotes Control of Leishmania major. J Immunol 197(10):4034-4041; PMID: 27798163
Hiergeist A, Gessner A (2016) Clinical implications of the microbiome in urinary tract diseases. Curr Opin Urol; PMID: 27898455
Altenbuchinger M, Rehberg T, Zacharias HU, Stämmler F, Dettmer K, Weber D, Hiergeist A, Gessner A, Holler E, Oefner PJ, Spang R (2016) Reference point insensitive molecular data analysis. Bioinformatics; PMID: 27634945
Weber D, Oefner PJ, Dettmer K, Hiergeist A, Koestler J, Gessner A, Weber M, Stämmler F, Hahn J, Wolff D, Herr W, Holler E (2016) Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant 51(8):1087-92; PMID: 26999466
Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R (2016) Adjusting microbiome profiles for differences in microbial load by spike-in bacteria. Microbiome 4:28; DOI 10.1186/s40168-016-0175-0
Dilger T, Melzl H, Gessner A (2016) Rapid and reliable identification of waterborne Legionella species by MALDI-TOF mass spectrometry. J Microbiol Methods 127 pp 154-159; PMID: 27260989
Pinkenburg O, Meyer T, Bannert N, Norley S, Bolte K, Czudai-Matwich V, Herold S, Gessner A, Schnare M (2016) The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus. PLoS One 6;11(6):e0156929; PMID: 27273104
Hiergeist A, Reischl U, Priority Program 1656 Intestinal Microbiota Consortium/quality assessment participants, Gessner A(2016) Multicenter quality assessment of 16S ribosomal DNA-sequencing formicrobiome analyses reveals high inter-center variability. Int J Med Microbiol; PMID: 27052158
Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L (2016) CD83 Modulates B Cell Activation and Germinal Center Responses. J Immunol; PMID: 26983787
Weber D, Oefner PJ, Dettmer K, Hiergeist A, Koestler J, Gessner A, Weber M, Stämmler F, Hahn J, Wolff D, Herr W, Holler E (2016) Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant; PMID: 26999466
Kesselring R, Glaesner J, Hiergeist A, Naschberger E, Neumann H, Brunner SM, Wege AK, Seebauer C, Köhl G, Merkl S, Croner RS, Hackl C, Stürzl M, Neurath MF, Gessner A, Schlitt HJ, Geissler EK, Fichtner-Feigl S (2016) IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Cancer Cell, available online 14 April 2016; doi:10.1016/j.ccell.2016.03.014
Dilger T, Melzl H, Gessner A (2016) Legionellen-Kontaminationen in Warmwassersystemen in Deutschland - Einfluss der maximal erreichbaren Temperatur und der Temperatur bei der Probenahme. gwf-Wasser/Abwasser, Ausgabe 03 2016
Lukas K, Thomas U, Gessner A, Wehner D, Schmid T, Schmid C, Lehle K (2016) Plasma functionalization of polycarbonaturethane to improve endothelialization—Effect of shear stress as a critical factor for biocompatibility control. Journal of Biomaterials Applications, Published online before print January 12, 2016, PMID: 26762398
Zach F, Mueller A, Gessner A (2015) Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells. PLoS ONE 10:e0142211; PMID: 26529319
Hiergeist A, Gläsner J, Reischl U, Gessner A (2015) Analyses of Intestinal Microbiota: Culture versus Sequencing. ILAR J 56(2):228-40; PMID: 26323632
Weber D, Oefner PJ, Hiergeist A, Koestler J, Gessner A, Weber M, Hahn J, Wolff D, Stämmler F, Spang R, Herr W, Dettmer K, Holler E (2015) Low urinary indoxyl sulfate levels early after ASCT reflect a disrupted microbiome and are associated with poor outcome. Blood 24 [Epub ahead of print]; PMID: 26209659
Knop J, Hanses F, Leist T, Archin NM, Buchholz S, Gläsner J, Gessner A, Wege AK (2015) Staphylococcus aureus Infection in Humanized Mice: A New Model to Study Pathogenicity Associated With Human Immune Response. J Infect Dis pii: jiv073 [Epub ahead of print]; PMID: 25657257
Holler E, Butzhammer P, Schmid K, Hundsrucker C, Koestler J, Peter K, Zhu W, Sporrer D, Hehlgans T, Kreutz M, Holler B, Wolff D, Edinger M, Andreesen R, Levine JE, Ferrara JL, Gessner A, Spang R, Oefner PJ (2014) Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease. Biol Blood Marrow Transplant 20(5):640-5; PMID: 24492144
Goldwich A, Burkard M, Ölke M, Daniel C, Amann K, Hugo C, Kurts C, Steinkasserer A, Gessner A (2013) Podocytes are nonhematopoietic professional antigen-presenting cells. J Am Soc Nephrol 24(6):906-16; PMID: 23539760
Goldwich A, Steinkasserer A, Gessner A, Amann K (2012) Impairment of podocyte function by diphtheria toxin-a new reversible proteinuria model in mice. Lab Invest 92:1674-85; PMID: 23007132
Rückert C, Licht K, Kalinowski J, Espírito Santo C, Antwerpen M, Hanczaruk M, Reischl U, Holzmann T, Gessner A, Tiemann C, Grass G (2012) Draft Genome Sequence of Bacillus anthracis UR-1, Isolated from a German Heroin User. J Bacteriol 194:5997-8; PMID: 23045504
Holzmann T, Frangoulidis D, Simon M, Noll P, Schmoldt S, Hanczaruk M, Grass G, Pregler M, Sing A, Hörmansdorfer S, Bernard H, Grunow R, Zimmermann R, Schneider-Brachert W, Gessner A, Reischl U (2012) Fatal anthrax infection in a heroin user from southern Germany, June 2012. Euro Surveill 17; PMID: 22790532
Sitte S, Gläsner J, Jellusova J, Weisel F, Panattoni M, Pardi R, Gessner A (2012) JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression. J Immunol 188:2677-86; PMID: 22327073
Böckl K, Wild J, Bredl S, Kindsmüller K, Köstler J, Wagner R (2012) Altering an artificial GagPolNef polyprotein and mode of Env co-administration affects the immunogenicity of a clade C HIV DNA vaccine. PLoS ONE 7:e34723; PMID: 22509350
Klaffenbach D, Friedrich D, Strick R, Strissel PL, Beckmann MW, Rascher W, Gessner A, Dötsch J, Meissner U, Schnare M (2011) Contribution of different placental cells to the expression and stimulation of antimicrobial proteins (AMPs). Placenta 32:830-7
Agwale SM, Forbi JC, Notka F, Wrin T, Wild J, Wagner R, Wolf H (2011) Broad Antibody Mediated Cross-Neutralization and Preclinical Immunogenicity of New Codon-Optimized HIV-1 Clade CRF02_AG and G Primary Isolates. PLoS One 6:e23233
Schulze J, Bickert T, Beil FT, Zaiss MM, Albers J, Wintges K, Streichert T, Klaetschke K, Keller J, Hissnauer TN, Spiro AS, Gessner A, Schett G, Amling M, McKenzie AN, Horst AK, Schinke T (2011) Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells. J Bone Miner Res 26:704-17
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol 90:551-62
First description of cytokine Elispot technique
Gessner A, Moskophidis D, Lehmann-Grube F (1989) Enumeration of single interferon-gamma producing cells in mice during viral and bacterial infection. J Immunol 142:1293-9