The surrounding of cancer cells (“tumor microenvironment) is a critical determinant of treatment responsiveness. Especially in many solid malignancies, the malformed tumor vasculature fails to meet the demand for oxygen. Oxygen deprivation renders many standard-of-care anti-cancer treatments significantly less effective compared to normoxic conditions. Notably, oxygen content is only one of many physico-chemical parameters that define the tumor environment. We are currently elucidating whether and how actively modifying the tumor microenvironment could enhance effectiveness of cancer therapies.
INSTITUT FÜR MIKROBIOLOGIE UND HYGIENE REGENSBURG
FRANZ-JOSEF-STRAUSS-ALLEE-11 D-93053 REGENSBURG