No cell lives in isolation. Interaction with the surrounding and adjustment to alterations is of vital importance. Consequently, every cell has to sense what is going on out there. Receptors located at the cell surface do exactly this job as they get activated for example by binding of cytokines and transmit these signals into the interior of the cell. Subsequently, these signals can result in changes of e.g. metabolism or protein production, which ensures proper adjustment to the current conditions.
Our group focuses on members of the Tumor-Necrosis-Factor Receptor superfamily. This group consists of more than 25 receptor-ligand pairs and has a plethora of roles in processes like inflammation, immunity & infection but also cancer. Detailed descriptions of the projects are listed below.
All current projects of our research group at a glance
Death Receptor 3 (DR3) belongs to the subgroup of so-called death receptors among the Tumor-Necrosis Factor (TNF) superfamily. DR3 is … Read more Signal transduction of Death Receptor 3
The surrounding of cancer cells (“tumor microenvironment) is a critical determinant of treatment responsiveness. Especially in many solid malignancies, the … Read more Targeting the tumor microenvironment to increase efficacy of cancer therapy